Development of novel method to eliminate Helicobacter pylori using bacteriolytic activity of bacteriophage

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Helicobacter pylori is a causative agent of gastritis and the stomach ulcer, and is also a risk factor of the stomach cancer. If H.pylori is detected at the patient's stomach, the elimination of it with the antibiotic agents is recommended. However, recent progress of antibiotic-resistance in H.pylori threatens the future of the elimination method. Therefore, we tried to get phage to develop the bacteriophage (phage) therapy system against H.pylori infection. As a result, a novel phage, φHP33, was isolated successfully. Phage φHP33 had a broad-host-range to many H.pylori strains and had strong lytic acitivity against them. Therefore, φHP33 is expected to be a good candidate as therapeutic phage for H.pylori infection.