Pathogenesis and establishment of new diagnosis and treatment of Chronic pulmonary aspergillosis

慢性肺曲霉菌病（CPA）发病机制复杂，与延误诊断、延误治疗有关。本研究旨在建立小鼠CPA模型，为CPA的诊断和治疗提供新的方法。在COPD小鼠中开发的CPA小鼠模型显示，与非COPD小鼠相比（不到一周），烟曲霉存在时间更长，持续三周。脂质体阿替霉素B吸入对肺曲霉菌病小鼠模型有明显的治疗作用。

Pathogenesis of chronic pulmonary aspergillosis (CPA) and complex and related to delayed diagnosis followed by delayed treatment. Aim of this study to establish the mouse CPA model and develop newer diagnosis method and treatment. CPA mouse model developed in COPD mice revealed the longer existence of Aspergillus fumigatus for three weeks compared to non-COPD mice (less than a week). Inhalation of liposomal amphotericin B was proved to be effective in pulmonary aspergillosis mouse model.