Effects of prenatal chemical substance exposure on the neurofunctions at the stage of CNS formation and neurobehavior at juvenile period.

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In this research project, we investigated the effect of prenatal exposure to 1-bromopropane (1BP), an alternative to chlorofluorocarbons, on the neurofunctions at the CNS-formation stage and neurobehavior at juvenile period, using rat animal models. As a result, we found that prenatal exposure to 1BP may alter hippocampal stimulus-responsive relationship at the CNS-formation stage, and exploration and short-term memory function at the juvenile period, suggesting that the prenatal exposure to chemicals could induce a postgrowth abnormality of neurobehavior.