Developmental neurotoxicity of volatile organic compounds: the evaluation of social behaviors and the developing of biomarkers

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The purpose of this research project is to evaluate developmental neurotoxicity of volatile organic compounds, and to explore a biomarker which can be applied to an evaluation index for the toxicity. We used model rats which were prenatally exposed to an organic solvent 1-bromopropane (1BP), and as a result, we found that a breeding environment soon after weaning day could affect exploration activity, although it was observed transiently. Additionally, we found that prenatal 1BP-exposure could enhance the development of the stimulation-response relationship in brain neural circuit, which could partly due to an accumulation of bromine ion in brain.