Analysis of T cell co-stimulatory molecules in secondary hemophagocytic syndrome.

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Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening conditions characterized by uncontrolled activation of T-cells and macrophages. The precise mechanism leading to the development of immune response dysregulation resulting in hypercytokinemia has not been well evaluated. We speculated and analyzed that T cell costimulatory molecules might be involved in the abnormal immune reactions in acquired HLH. Our results suggest that CTLA-4 polymorphism might play a role in the development of acquired HLH.