The mechanism of development and exacerbation of virus-induced asthma analyzed by a lipid mediator gene knock-out mice

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To clarify the pathogenesis of exacerbations of asthma due to viral infection, we examined bronchial resistance, peripheral blood and bronchial alveolar fluid (BALF) analyses and multiple types of cytokines/chemokines using an experimental asthma model mice infected with respiratory syncytial virus (RSV). The levels of BALF and tissue eosinophils showed significant increase in ovalbumin (OVA) and OVA/RSV groups compared with controls. MIP-1αin BALF was significantly increased in OVA/RSV groups compared with RSV groups, OVA groups, and control groups. Serum IL-5 in OVA groups and serum IL-17 in OVA/RSV groups were also higher than in controls. These findings suggest that eosinophilic inflammation via MIP-1α may play an important role in acute exacerbations of asthma model induced by RSV.