Activation-Induced Cytidine Deaminase (AID) Links epidermal Inflammation to malignant skin tumors

AID是一种DNA突变酶，在炎症性皮肤病中有表达，包括扁平苔藓、硬化性苔藓和萎缩性苔藓和DLE。AID在人角质形成细胞系中不表达，但加入炎性细胞因子肿瘤坏死因子-α可诱导该细胞系异位表达AID。这些数据表明，皮肤持续炎症导致角质形成细胞异位表达AID。由于AID的异常表达，该酶可诱导DNA突变和皮肤癌的发生。

AID, a DNA mutagenic enzyme, was expressed in inflammatory skin disorders, including lichen planus, lichen sclerosis et atrophicus and DLE. The AID was not expressed in human keratinocyte cell line, however, addition of TNF-a, a inflammatory cytokine, induced the ectopic expression of AID in this cell line. These data suggested that sustained inflammation in skin yielded the ectopic expression of AID in keratinocytes. As a result of aberrant expression of AID, the enzyme induces DNA mutation and skin carcinogenesis.