Activation-Induced Cytidine Deaminase (AID) Links epidermal Inflammation to malignant skin tumors

激活诱导的胞苷脱氨酶 (AID) 将表皮炎症与恶性皮肤肿瘤联系起来

• 批准号: 20591317
• 负责人: HARADA Kazutoshi
• 金额: $ 2.66万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591317/
• 关键词: 皮膚悪性腫瘍; 慢性炎症; 遺伝子変異; AID(activation induced deaminase); 皮膚腫瘍; 発癌; シグナル伝達

AID, a DNA mutagenic enzyme, was expressed in inflammatory skin disorders, including lichen planus, lichen sclerosis et atrophicus and DLE. The AID was not expressed in human keratinocyte cell line, however, addition of TNF-a, a inflammatory cytokine, induced the ectopic expression of AID in this cell line. These data suggested that sustained inflammation in skin yielded the ectopic expression of AID in keratinocytes. As a result of aberrant expression of AID, the enzyme induces DNA mutation and skin carcinogenesis.

AID是一种DNA致突变酶，在炎症性皮肤病中表达，包括扁平苔藓、硬化萎缩性苔藓和DLE。AID在人角质形成细胞系中不表达，然而，加入炎性细胞因子TNF-α诱导AID在该细胞系中异位表达。这些数据表明，皮肤中持续的炎症导致角质形成细胞中AID的异位表达。由于AID的异常表达，该酶诱导DNA突变和皮肤癌发生。

项目成果

Overexpression of GRIM-19 in Cancer Cells Suppresses STAT3-Mediated Signal Transduction and Cancer Growth

• DOI: 10.1158/1535-7163.mct-09-1147
• 发表时间: 2010-08
• 期刊: Molecular Cancer Therapeutics
• 影响因子: 5.7
• 作者: Takashi Okamoto;T. Inozume;H. Mitsui;M. Kanzaki;K. Harada;N. Shibagaki;S. Shimada

Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.

• DOI: 10.1158/0008-5472.can-08-1963
• 发表时间: 2009-05-01
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Scholl FA;Dumesic PA;Barragan DI;Harada K;Charron J;Khavari PA
• 通讯作者: Khavari PA

A case of lymphoepithelioma-like carcinoma of the skin associated with EpsteineBarr virus infection.

与 EpsteineBarr 病毒感染相关的皮肤淋巴上皮瘤样癌一例。

• 发表时间: 2010
• 期刊: J AM ACAD DERMATOL. 62(4)
• 作者: Aoki R;Mitsui H;Harada K;Kawamura T;Shibagaki N;Tsukamoto K;Murata S;Shimada S
• 通讯作者: Shimada S

Psoriasiform eruption associated with alopecia areata during infliximab therapy.

英夫利昔单抗治疗期间与斑秃相关的银屑病样皮疹。

• 发表时间: 2009
• 期刊: Clin Exp Dermatol. 34(8)
• 作者: Nakagomi D;Harada K;Yagasaki A;Kawamura T;Shibagaki N;Shimada S.
• 通讯作者: Shimada S.

遺伝子変異誘導酵素AID の皮膚悪性腫瘍発生における役割の解明

阐明基因突变诱导酶AID在皮肤恶性肿瘤发生中的作用

• 发表时间: 2009
• 作者: 原田和俊;島田眞路
• 通讯作者: 島田眞路