Relationship between the effectiveness of repetitive transcranial magnetic stimulation (rTMS) and brain images in the treatment for major depression.

[研究1]本研究的目的是研究慢性rTMS对大鼠海马神经发生的影响。在rTMS治疗组，BrdU阳性细胞在齿状回显着增加。我们的研究结果表明，海马神经发生可能参与慢性rTMS的抗抑郁作用。[研究2]使用重复经颅磁刺激（rTMS）治疗抑郁症的反应者和非反应者，反应者治疗前Cg 25灌注较高，治疗后降低。我们的研究结果表明，rTMS治疗反应可能与治疗前的Cg25活性和调制的Cg25。

【Study1】The aim of this study was to examine chronic rTMS effects on hippocampal neurogenesis in rats. In the rTMS-treated group, BrdU-positive cells were significantly increased in the dentate gyrus. Our results suggest that hippocampal neurogenesis might be involved in the antidepressant effects of chronic rTMS.【Study2】Using a responder and a non-responder of repetitive transcranial magnetic stimulation (rTMS) for depression, pre-treatment Cg25 perfusion was higher and was decreased after treatment in the responder. Our results suggest that rTMS treatment response may be related to pre-treatment Cg25 activity and modulation of the Cg25.