Cortical excitability in schizophrenic patients studied by transcranial magnetic stimulation.

运动皮质的短暂性抑制是通过成对的经颅磁刺激获得的，这种抑制可能主要由含有γ-氨基丁酸的神经元介导。预脉冲抑制(PPI)是通过惊厥听觉配对刺激获得的，可能反映了多巴胺-NMDA的功能。精神分裂症患者在典型的抗精神病药物治疗、高BPRS核心和低GAF评分的精神分裂症患者中发现配对SICI，且在无序型比妄想型更常见。在一些患者中，SICI受损被认为是一种特征标记。精神分裂症患者在60ms和480ms条件下发现PPI异常。PPI与人口学评分(发病年龄、病程、每日服药总量和尼古丁)、精神状态测量(PANSS、GAF)和认知功能评分(MMSE、FAB、ATMT)之间没有显著相关性，提示PPI很可能成为一个特征标记。SICI、PPI似乎很好地成为早期干预和预测临床结果的生理学依据。

Short intracortical inhibition (SICI) of motor cortex is obtained with paired transcranial magnetic stimulation (TMS) and is probably largely mediated by neurons containing γ-aminobutyric acid (GABA). Prepulse inhibition (PPI) is obtained using startled auditory paired stimulation and probably reflects the Dopamine-NMDA function.Impaired SICI was found in schizophrenic patients with typical anti-psychotics medications, high BPRS core and low GAF score, and more frequently found in disorganized type than in delusional type. Impaired SICI was thought to be a trait marker in some patients,.PPI abnormality was found in 60ms and 480ms conditions in schizophrenic patients. No significant correlation was found between PPI and demographic scores (onset age, duration of illness, total amount of medication and nicotine per day), mental state measurements (PANSS, GAF) and cognitive function scores (MMSE, FAB, ATMT), suggesting that PPI may well became a trait marker.SICI, PPI appear to well become a physiological stool for early intervention and a prediction of clinical outcome.