Cortical excitability in schizophrenic patients studied by transcranial magnetic stimulation.

通过经颅磁刺激研究精神分裂症患者的皮质兴奋性。

• 批准号: 17591228
• 负责人: SHINOSAKI Kazuhiro
• 金额: $ 2.24万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591228/
• 关键词: schizophrenia; transcranial magnetic stimulation; startled auditory stimulation; TMS; PPI; GABA; NMDA; 経頭蓋磁気刺激TMS; 運動閾値; prepulse inhibition (PPI); ICI; ICF

Short intracortical inhibition (SICI) of motor cortex is obtained with paired transcranial magnetic stimulation (TMS) and is probably largely mediated by neurons containing γ-aminobutyric acid (GABA). Prepulse inhibition (PPI) is obtained using startled auditory paired stimulation and probably reflects the Dopamine-NMDA function.Impaired SICI was found in schizophrenic patients with typical anti-psychotics medications, high BPRS core and low GAF score, and more frequently found in disorganized type than in delusional type. Impaired SICI was thought to be a trait marker in some patients,.PPI abnormality was found in 60ms and 480ms conditions in schizophrenic patients. No significant correlation was found between PPI and demographic scores (onset age, duration of illness, total amount of medication and nicotine per day), mental state measurements (PANSS, GAF) and cognitive function scores (MMSE, FAB, ATMT), suggesting that PPI may well became a trait marker.SICI, PPI appear to well become a physiological stool for early intervention and a prediction of clinical outcome.

运动皮层的短皮质内抑制（SICI）是通过成对经颅磁刺激（TMS）获得的，并且可能主要由含有γ-氨基丁酸（GABA）的神经元介导。前脉冲抑制（Prepulse inhibition，PPI）可能反映了多巴胺-NMDA功能，SICI受损见于服用典型抗精神病药物、BPRS核心评分高、GAF评分低的精神分裂症患者，且紊乱型患者较妄想型患者多见。SICI受损被认为是部分患者的一个特征性标志，PPI在60 ms和480 ms时出现异常。PPI与人口学评分（发病年龄、病程、每日用药总量和尼古丁用量）、精神状态量表（PANSS、GAF）和认知功能评分（MMSE、FAB、ATMT）均无显著相关性，提示PPI可作为一种特质指标，SICI、PPI可作为早期干预和预测临床结局的生理指标。

项目成果

情動を脳波で測定する

使用脑电波测量情绪

• 发表时间: 2006
• 期刊: 臨床脳波 Vol.48,No.10
• 作者: 岡田康秀;林拓世;Okada Y.;Hayashi T.;岡田康秀;林拓世;水野(松本)由子
• 通讯作者: 水野(松本)由子

Spatially filtered magnetoencephalographic analysis of cortical oscillatory changes in basic brain rhythms during the Japanese Shiritori word generation task.

日语 Shiritori 单词生成任务期间基本大脑节律的皮质振荡变化的空间过滤脑磁图分析。

• 发表时间: 2006
• 期刊: Biochem. Biophys. Res. Commun. 344(2)
• 作者: Kudo T;Takeda M;et al.
• 通讯作者: et al.

Right parietal activation during delusional state in episodic interictal psychosis of epilepsy: A report of two cases

• DOI: 10.1016/j.yebeh.2006.06.017
• 发表时间: 2006-09-01
• 期刊: EPILEPSY & BEHAVIOR
• 影响因子: 2.6
• 作者: Ishii, R.;Canuet, L.;Takeda, M.
• 通讯作者: Takeda, M.

高齢者に特有な精神症候群7.音楽性幻聴.「現代老年精神医療」武田雅俊編

老年人特有的精神综合症7.音乐幻听，武田正敏主编的《现代老年精神病学》。

• 发表时间: 2005
• 作者: 鵜飼聡;山本雅清;篠崎和弘
• 通讯作者: 篠崎和弘

Donepezil in the treatment of musical hallucinations

• DOI: 10.1111/j.1440-1819.2007.01636.x
• 发表时间: 2007-04-01
• 期刊: PSYCHIATRY AND CLINICAL NEUROSCIENCES
• 影响因子: 11.9
• 作者: Ukai, Satoshi;Yamamoto, Masakiyo;Takeda, Masatoshi
• 通讯作者: Takeda, Masatoshi