Parallel distributed processing neuroimaging in schizophrenic patients during the frontal tasks

精神分裂症患者额叶任务期间的并行分布式处理神经影像

• 批准号: 15591222
• 负责人: SHINOSAKI Kazuhiro
• 金额: $ 2.24万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591222/
• 关键词: schizophrenia; magnetoencephalogram; hallucination; prefrontal cortex; Stroop task; words generation task; parallel distributed processing; スツループ課題; ネットワーク

Using a spatially filtered magnetoencephalography(MEG) analysis, SAM(synthetic aperture magnetometry), we estimated parallel distributed processing of the neural activations in the Stroop task and in the words generation task for schizophrenic patients with/without auditory hallucinations and for normal control subjects.In the Stroop task, one hundred unaveraged MEG signals from the presentation of incongruent stimulus to responses were analyzed with a time window of 200 ms in steps of 50 ms. In the 25-60 Hz band, cortical regions that showed significant current source density(CSD) changes were examined for each time window. The three groups showed significantly decreased CSD, corresponding to neural activation, with temporal overlap along the fundamental cognitive information processing flow : sensory input system-executive control system-motor output system with 300ms, 350ms, 450ms time latency respectively. Transient neural activations in the dorsolateral prefrontal cortex(DLPFC) were bilateral with left-side dominancy for the normal controls, left-lateralized for the non-hallucinators and right-lateralized for the hallucinators. Our results suggest that the dysfunction in the left DLPFC was related to auditory hallucinations, while the information processing flow was unaffected in the schizophrenic subjects in the Stroop task.In the words generation task, no patients showed activation in the post superior temporal gyrus, while almost all normal subjects showed it, suggesting the dysfunction of self-monitoring around the Wernicke area. No patients with auditory hallucination showed activation in the post inferior frontal gyrus, while patients without auditory hallucination did not show it, suggesting the dysfunction in the inner-speech around the Broca area.These time high resolution neuroimages might contribute the developing a new treatment using repetitive transcranial magnetic stimulation or the selection of high risk subjects for the early intervention.

使用空间滤波脑磁图（MEG）分析，SAM（合成孔径磁测法），我们估计了有/无幻听的精神分裂症患者和正常对照受试者在Stroop任务和单词生成任务中的神经激活的并行分布处理。以200 ms的时间窗以50 ms的步长分析了来自不一致刺激到反应的呈现的100个非平均MEG信号。在25-60 Hz频带中，对每个时间窗检查显示显著电流源密度（CSD）变化的皮质区域。3组均表现出明显的CSD降低，对应于神经元的激活，在基本的认知信息加工流程：感觉输入系统-执行控制系统-运动输出系统上存在沿着时间重叠，潜伏期分别为300 ms、350 ms、450 ms。在背外侧前额叶皮层（DLPFC）的瞬时神经激活是双边的左侧优势的正常对照组，左侧的非幻觉和右侧的幻觉。结果表明，左侧DLPFC的功能障碍与幻听有关，而Stroop任务中精神分裂症患者的信息加工流程不受影响;在单词生成任务中，没有患者出现上级颞后回激活，而几乎所有正常人都出现激活，提示Wernicke区周围的自我监控功能障碍。有幻听的患者额下回无激活，而无幻听的患者额下回无激活，提示Broca区周围的言语功能障碍，这些高分辨率的神经影像可能有助于开发重复经颅磁刺激治疗的新方法或早期干预高危人群的选择。

项目成果

統合失調症患者の前頭前野・言語関連領野の活動のMEG研究

精神分裂症患者前额皮质和语言相关区域活动的MEG研究

• 发表时间: 2003
• 期刊: 臨床脳波 45
• 作者: 谷井久志;武田雅俊;鵜飼聡
• 通讯作者: 鵜飼聡

Slow repetitive transcranial magnetic stimulation increases somatosensory high-frequency oscillations in humans

缓慢重复经颅磁刺激增加人体体感高频振荡

• 发表时间: 2004
• 期刊: Neuroscience Letters 359
• 作者: Asao Ogawa;et al.
• 通讯作者: et al.

Information processing flow and neural activation in the dorsolateral prefrontal cortex in the Stroop task in Schizophrenic patients

精神分裂症患者 Stroop 任务中背外侧前额叶皮层的信息处理流程和神经激活

• 发表时间: 2005
• 期刊: Neuropshchobiology (In press)
• 作者: 稲田俊也;岩本邦弘;Kawaguchi S
• 通讯作者: Kawaguchi S

K Shinosaki, R Ishii, S Ukai, Y Mizuno-Matsumoto, T Inouye, M Tutiyama, T Kaku, M Takeda: "Effect of healthy aging on brain functional connectivity : a EEG study."Psychogeriatrics. 3. 44-53 (2003)

K Shinosaki、R Ishii、S Ukai、Y Mizuno-Matsumoto、T Inouye、M Tutiyama、T Kaku、M Takeda：“健康衰老对大脑功能连接的影响：脑电图研究。”精神病学。

Investigation of aging of parallel distributed processing in the Stroop task using spatially filtered MEG analysis

使用空间过滤 MEG 分析研究 Stroop 任务中并行分布式处理的老化

• 发表时间: 2003
• 期刊: Psychiatry and Clinical Neurosciences 57
• 作者: 渡邊 崇;下田和孝;Y.Suzuki et al.;Yamamoto M;Ryouhei Ishii et al.;Masakiyo Yamamoto et al.;Eiko Honaga et al.;Shunsuke Kawaguchi et al.;Kazuhiro Shinosaki et al.;Kazuhiro Shinosaki et al.;Satoshi Ukai et al.
• 通讯作者: Satoshi Ukai et al.