Development of amyloid and tau imaging probes for early diagnosis of dementia

开发淀粉样蛋白和 tau 蛋白成像探针用于痴呆症的早期诊断

• 批准号: 20591432
• 负责人: OKAMURA Nobuyuki
• 金额: $ 2.91万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591432/
• 关键词: 認知症; 神経科学; 放射線; 脳神経疾患; 老化; PET; アルツハイマー病; アミロイドβ蛋白

Noninvasive visualization of amyloid-ss (Ass) and tau deposits in the living brain will contribute to a better understanding of the pathophysiology of Alzheimer's disease (AD). Although in vivo Ass imaging probes for positron emission tomography (PET) are currently available, in vivo tau imaging agent is still unavailable for clinical study. As candidate probes for PET tau imaging, we developed novel compounds named [^<18>F]THK-523 and [^<11>C]THK-951. These two compounds showed high binding affinity and specificity to tau protein and high brain-blood barrier permeability.

脑内淀粉样蛋白(Ass)和tau蛋白沉积的非侵入性可视化有助于更好地了解阿尔茨海默病(AD)的病理生理机制。虽然目前已有用于正电子发射断层扫描(PET)的体内Ass显像剂，但体内tau显像剂仍不能用于临床研究。作为PET tau成像的候选探针，我们开发了新的化合物[^&lt；18&gt；F]THK-523和[^&lt；11&gt；C]THK-951。这两个化合物对tau蛋白具有较高的亲和力和特异性，并具有较高的脑血屏障通透性。

项目成果

Imaging Amyloid Pathology in the Living Brain

• DOI: 10.2174/157340508783502840
• 发表时间: 2008-01
• 期刊: Current Medical Imaging Reviews
• 作者: N. Okamura;S. Furumoto;H. Arai;R. Iwata;K. Yanai;Y. Kudo

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Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-11C-methoxy]donepezil

• DOI: 10.1016/j.neuroimage.2009.03.006
• 发表时间: 2009-07-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Hiraoka, Kotaro;Okamura, Nobuyuki;Watabe, Hiroshi
• 通讯作者: Watabe, Hiroshi

Development of novel imaging probe for senile plaques and neurofibrillary tangles.

开发用于老年斑和神经原纤维缠结的新型成像探针。

• 发表时间: 2010
• 作者: Okamura N;Kudo Y.
• 通讯作者: Kudo Y.

Methamphetamine-and 3, 4-Methylenedioxymethamphetamine-Induced Behavioral Changes in Histamine H(3)-Receptor Knockout Mice

甲基苯丙胺和 3, 4-亚甲二氧基甲基苯丙胺诱导组胺 H(3)-受体基因敲除小鼠的行为变化

• 发表时间: 2009
• 期刊: J Pharmacol Sci
• 影响因子: 3.5
• 作者: Okuda T;Zhang D;Shao H;Okamura N;Takino N;Iwamura T;Sakurai E;Yoshikawa T;Yanai K
• 通讯作者: Yanai K