Clinical application of tau PET probes

tau PET探针的临床应用

• 批准号: 23390297
• 负责人: OKAMURA Nobuyuki
• 金额: $ 12.4万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390297/
• 关键词: 痴呆; 神経科学; 放射線; 脳神経疾患; 老化

To detect tau protein deposits in the living brain, [18F]THK-5105 and [18F]THK-5117 have been developed as tau PET probes. In vitro binding assay and autoradiography demonstrated the high binding affinity and selectivity of these probes to tau pathology in Alzheimer's disease (AD) brains. First-in-man PET studies have been performed to assess the clinical usefulness of these probes. AD patients showed THK-5105 and THK-5117 retention in the lateral and medial temporal cortices that are known to contain high density of tau deposits. Regional distribution of these tracers differed considerably from that of PiB. In addition, the retention of these tracers was correlated with clinical severity and brain atrophy in AD patients. From these findings, [18F]THK-5105 and [18F]THK-5117 are considered to be useful for the non-invasive assessment of tau pathology.

为了检测活体大脑中tau蛋白的沉积，已经开发出[18F]THK-5105和[18F]THK-5117作为tau PET探针。体外结合分析和放射自显影表明，这些探针对阿尔茨海默病(AD)脑内的tau病理具有高的结合亲和力和选择性。已经进行了第一次人体正电子发射计算机断层扫描研究，以评估这些探头的临床用途。AD患者THK-5105和THK-5117显示THK-5105和THK-5117滞留在已知含有高密度tau沉积的外侧和内侧颞叶皮质。这些示踪剂的区域分布与PIB的区域分布有很大差异。此外，这些示踪剂的保留与AD患者的临床严重程度和脑萎缩相关。根据这些发现，[18F]THK-5105和[18F]THK-5117被认为对tau病理的非侵入性评估是有用的。

项目成果

Molecular imaging of misfolded proteins

错误折叠蛋白质的分子成像

• 发表时间: 2011
• 作者: 岡村信行、原田龍一;他
• 通讯作者: 他

Near-infrared fluorescence probe X50 for in vivo detection of amyloid plaques in the brain

用于体内检测大脑中淀粉样斑块的近红外荧光探针 X50

• 发表时间: 2011
• 作者: Okamura N;Furumoto S;Harada R;Arai H;Y anai K;Kudo Y
• 通讯作者: Kudo Y

PET tau imaging in Alzheimer's disease using novel 18F-labeled 2-phenylquinoline derivatives.

使用新型 18F 标记的 2-苯基喹啉衍生物对阿尔茨海默病进行 PET tau 成像。

• 发表时间: 2013
• 作者: Okamura N;Furumoto S;Harada R;Fodero-Tavoletti MT;Mulligan RS;Masters CL;Yanai K;Kudo Y;Rowe CC;Villemagne VL.
• 通讯作者: Villemagne VL.

Synthesis of [^(11)C]interleukin 8 using a cell-free translation system and l-[^(11)C]methionine

使用无细胞翻译系统和 l-[^(11)C]蛋氨酸合成 [^(11)C]白细胞介素 8

• DOI: 10.1016/j.nucmedbio.2011.07.005
• 发表时间: 2012
• 期刊: Nucl Med Biol
• 影响因子: 3.1
• 作者: Harada R;Furumoto S;Y oshikawa T;Ishikawa Y;Shibuya K;Okamura N;Iwata R;Y anai K
• 通讯作者: Y anai K

Comparison of the binding Comparison of the binding

绑定对比 绑定对比

• 发表时间: 2013
• 期刊: Eur J Nucl Med Mol Imaging
• 作者: Harada R;Okamura N;Furumoto S;Tago T;Maruyama M;Higuchi M;Y oshikawa T;Arai H;Iwata R;Kudo Y;Y anai K
• 通讯作者: Y anai K