Science of Sho based on a metabolism study in the bowels of glucosides of Kampo medicine

用大鼠粪便悬浮液对甘草酸苷代谢的研究表明，甘草酸苷的摄入显著激活了甘草酸苷的代谢，其中甘草酸苷的摄入显著提高了某些大鼠(应答者)的甘草酸代谢，而在另一些大鼠(无应答者)中则没有。由于肠道菌群被认为是应答者和无应答者之间的差异的原因，我们试图通过调查长期服用和禁食对甘草酸代谢的影响来确定那些与甘草酸消费反应相关的因素。结果表明，长期服用甘草酸苷和禁食可导致无反应者。老鼠变成了响应者。由于禁食是甘草酸苷摄入反应中最重要的因素，禁食似乎是甘草酸苷肠道代谢的主要促进剂之一。鉴于这种非侵入性和方便的代谢研究可以确定甘草酸苷等前体药物的代谢，这项技术也可能有助于识别草药和中药的应答者。此外，通过比较尿钾和血压，研究了对甘草酸苷消耗的反应与假醛固酮增多症的关系，但这些参数在应答者和无应答者之间没有显著差异。

A study of glycyrrhizin metabolism using rat fecal suspensions showed that glycyrrhizin consumption significantly activated glycyrrhizin metabolism, with glycyrrhizin consumption significantly elevating glycyrrhizin metabolism in some rats (responders) but not in others (nonresponders). Since intestinal microflora are believed to be responsible for the difference between responders and nonresponders, an attempt was made to identify those factors associated with the response to glycyrrhizin consumption by investigating the effects of long-term consumption and fasting on glycyrrhizin metabolism. The results showed that long-term glycyrrhizin consumption and fasting caused nonresponder. rats to become responders. Since fasting was the most significant factor in the response to glycyrrhizin consumption, fasting appears to be one of the major facilitators of intestinal metabolism of glycyrrhizin. Given that this noninvasive and convenient metabolic study could ascertain the metabolism of prodrugs such as glycyrrhizin, the technique could also be useful for identifying responders to herbal and Chinese medicines. Furthermore, the relationship between the response to glycyrrhizin consumption and pseudoaldosteronism was investigated by comparing urinary potassium and blood pressure, but no significant differences in these parameters were observed between responders and nonresponders.