Science of Sho based on a metabolism study in the bowels of glucosides of Kampo medicine

一项利用大鼠粪便悬浮液对甘草酸代谢的研究表明，甘草酸的摄入显著激活了甘草酸的代谢，在一些大鼠（有反应的）中，甘草酸的摄入显著提高了甘草酸的代谢，而在其他大鼠（无反应的）中则没有。由于肠道菌群被认为对应答者和无应答者之间的差异负责，因此我们试图通过研究长期摄入和禁食对甘草酸代谢的影响来确定与甘草酸摄入应答相关的因素。结果表明，长期服用甘草酸和禁食导致无应答。老鼠成为反应者。由于禁食是对甘草酸消耗反应的最重要因素，因此禁食似乎是甘草酸肠道代谢的主要促进因素之一。鉴于这种无创和方便的代谢研究可以确定前药如甘草酸的代谢，该技术也可用于识别对草药和中药的反应。此外，通过比较尿钾和血压，研究了对甘草酸消耗的反应与假醛固酮增多症之间的关系，但在反应者和无反应者之间没有观察到这些参数的显著差异。

A study of glycyrrhizin metabolism using rat fecal suspensions showed that glycyrrhizin consumption significantly activated glycyrrhizin metabolism, with glycyrrhizin consumption significantly elevating glycyrrhizin metabolism in some rats (responders) but not in others (nonresponders). Since intestinal microflora are believed to be responsible for the difference between responders and nonresponders, an attempt was made to identify those factors associated with the response to glycyrrhizin consumption by investigating the effects of long-term consumption and fasting on glycyrrhizin metabolism. The results showed that long-term glycyrrhizin consumption and fasting caused nonresponder. rats to become responders. Since fasting was the most significant factor in the response to glycyrrhizin consumption, fasting appears to be one of the major facilitators of intestinal metabolism of glycyrrhizin. Given that this noninvasive and convenient metabolic study could ascertain the metabolism of prodrugs such as glycyrrhizin, the technique could also be useful for identifying responders to herbal and Chinese medicines. Furthermore, the relationship between the response to glycyrrhizin consumption and pseudoaldosteronism was investigated by comparing urinary potassium and blood pressure, but no significant differences in these parameters were observed between responders and nonresponders.