The effect of i nterleukin-17 producing CD4+ T cells (T_H-17 cells) on immune system and progression of digestive cancer.

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In the current study, we determined the frequency of T_H-17 cells obtained from gastric cancer patients. In addition, clinical significance of IL-17 that is mainly produced by T_H-17 cells was determined in gastric cancer patients. The frequency of T_H-17 cells in the tissue of gastric cancer was significantly more than those in peripheral blood. The concentration of IL-17, hallmark of T_H-17, in gastric cancer patients was significantly higher than that in normal controls. The prognosis of gastric cancer patients with high IL-17 concentration was significantly poor than that with low IL-17 concentration. Furthermore, multivariate analysis indicated that IL-17 concentration was an independent prognostic indicator as well as lymph node metastasis was. In conclusion, T_H-17 cells may play an extremely important role in the progression of gastric cancer though the IL-17 production.