In Carcinogenesis of colon and rectum, abnormality of tumor cell polarity is induced by expression change of aPKC/PAR system

结直肠癌发生过程中，aPKC/PAR系统表达变化导致肿瘤细胞极性异常

• 批准号: 20591592
• 负责人: ICHIKAWA Yasushi
• 金额: $ 2.25万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591592/
• 关键词: 大腸腺腫; aPKC; 細胞極性; 大腸腫瘍; 大腸癌

Both adenoma and cancer in situ of LSTs showed a unique growth morphology as neoplastic cells tend to spread along the surface of the lumen and 2 layer structure, which is different from expanding growth pattern showed by polypoid tumor or invasive cancer. Those morphological characteristics were built up by adequate coexpression of beta-catenin, type IV collagen and aPKC lambda/iota.

LST的腺瘤和原位癌均表现出独特的生长形态，肿瘤细胞倾向于沿管腔表面沿着2层结构扩散，这与息肉样肿瘤或浸润性癌表现出的扩张生长模式不同。这些形态学特征是通过β-连环蛋白、IV型胶原和aPKC λ/i的充分共表达而建立的。

项目成果

High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence.

非典型蛋白激酶 C lambda/iota 在胃癌中的高表达作为复发的预后因素。

• 发表时间: 2009
• 期刊: Ann Surg Oncol 17(1)
• 作者: Takagawa R;Akimoto K;Ichikawa Y;Akiyama H;Kojima Y;Ishiguro H;Inayama Y;Aoki I;Kunisaki C;Endo I;Nagashima Y;Ohno S
• 通讯作者: Ohno S

The over- expression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors.

乳腺癌中非典型蛋白激酶C lambda/iota 的过度表达和定位改变与这些肿瘤的病理类型相关。

• 发表时间: 2008
• 期刊: Hum Pathol 39(6)
• 作者: Kojima Y;Akimoto K;Nagashima Y;Ishiguro H;Shirai S;Chishima T;Ichikawa Y;Ishikawa T;Sasaki T;Kubota Y;Inayama Y;Aoki I;Ohno S;Shimada H
• 通讯作者: Shimada H

Expression of the atypical protein kinase C combined with expression of other factors is important for determination of structures in lateral spreading type tumors of the colon or the rectum

非典型蛋白激酶 C 的表达与其他因子的表达相结合对于确定结肠或直肠侧向扩散型肿瘤的结构非常重要

• 发表时间: 2010
• 作者: Yasushi Ichikawa;et al
• 通讯作者: et al

Expression of the atypical protein kinase C in lateral spreading type tumors of the colon or the rectum.

非典型蛋白激酶 C 在结肠或直肠侧向扩散型肿瘤中的表达。

• 发表时间: 2009
• 作者: Ichikawa Y;Kojima Y;Ishikawa T;Shimizu D;Goto A;Hirokawa S;Kijima M;Yamamoto H;Suwa H;Yamagishi S;Osada S;Ota M;Fujii S;Endo I;Shimada H;Akimoto K;Nagashima Y;Ohno S
• 通讯作者: Ohno S

大腸lateral spreading tumor(LST)におけるatypical protein kinase C発現の意義(Expression of the atypical protein kinase C in lateral spreading type tumors of the colon or the rectum)

非典型蛋白激酶C在结肠或直肠侧向扩散型肿瘤中的表达

• 发表时间: 2009
• 作者: 市川靖史、長嶋洋治;他
• 通讯作者: 他