MECHANISM OF PERINEUTAL INVASION OF PANCREATIC CANCER-USING IMMUNOHISTOCHEMICAL TECHNIQUE NCAM PSA-

胰腺癌肾周侵袭机制——免疫组化技术NCAM PSA-

• 批准号: 10671208
• 负责人: ICHIKAWA Yasushi
• 金额: $ 1.15万
• 依托单位: YOKOHAMA CITY UNIVERSITY, SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671208/
• 关键词: Pancreatic Cancer; NCAM; Polycyclic Acid; Neural Invasion; 神経周囲浸潤; Neural Cell Adhesion Molecule

Neurotoropism of pancreatic cancer is one of the hypotheses explaining neural invasion, which is one of the characteristics of pancreatic cancer. In these studies we Immunohistochemically examined neural cell adhesion molecule (NCAM), hemophilic adhesion molecules expressed on the nerve cells, as a factor of neurotropism in 15 pancreatic cancer operatively obtained, especially In neural Invasive lesions. We also Investigated the role of polycyclic acid (PSA), which is attached to NCAM and related to the malignant potential of cancers. NCAM was detected In 66.7% of pancreatic cancers, and all 9 cases with massive pleural invasion. In neural invasion, however, there were perineurium and endoneurium, which do not express NCAM, between cancer and the nerve cells. PSA was also detected pancreatic cancers expressing NCAM. Moreover, PSA expression was stronger In the perineural Invasive lesions than in the main tumor and was related to the cancer cell proliferation Investigated by Ki-67 staining. It is unlikely therefore, that NCAN plays an Important role in neurotropism. However, the NCAM expressed on the pancreatic cancer was attached to PSA, which itself plays an Important role In the malignant potential of this disease.

神经侵袭是胰腺癌的特征之一，而神经侵袭是胰腺癌的重要病理特征之一。在这些研究中，我们免疫组化检测神经细胞粘附分子（NCAM），表达在神经细胞上的血友病粘附分子，作为一个因素的嗜神经性在15胰腺癌手术获得，特别是在神经浸润性病变。我们还研究了多环酸（PSA）的作用，它附着在NCAM上，与癌症的恶性潜能有关。NCAM在胰腺癌中的阳性率为66.7%，且9例均伴有巨大胸膜侵犯。而在神经浸润中，在癌细胞和神经细胞之间存在不表达NCAM的神经束膜和神经内膜。PSA也在表达NCAM的胰腺癌中检测到。此外，PSA在神经周围浸润性病变中的表达强于主瘤，并与Ki-67染色所研究的癌细胞增殖有关。因此，NCAN不太可能在嗜神经性中发挥重要作用。然而，胰腺癌上表达的NCAM附着于PSA，PSA本身在该疾病的恶性潜能中起重要作用。

项目成果

K kameda, H Shimada, T Ishikawa, A takimoto, N Momiyama, S Hasegawa, K Misuta, A nakano, Y Nagashima, Y Ichikawa: "Expression of highly polysialylated neural cell adhesion molecule in pancreatic cancer neural invasive lesion"Cancer Letters. 137. 201-207 (

K kameda、H Shimada、T Ishikawa、A takimoto、N Momiyama、S Hasekawa、K Misuta、A nakano、Y Nagashima、Y Ichikawa：“胰腺癌神经浸润性病变中高度聚唾液酸化的神经细胞粘附分子的表达”癌症快报。

亀田久仁郎, 簾田康一郎他: "膵臓癌の神経浸潤における神経細胞接着因子(NCAM)ポリシアル酸(PSA)発現の意義"肝胆膵. 34. 357-364 (1997)

Kuniro Kameda、Koichiro Ranada 等人：“神经元细胞粘附因子 (NCAM) 聚唾液酸 (PSA) 在胰腺癌神经侵袭中的表达意义”肝胆胰病学 34. 357-364 (1997)。

K.KAMEDA, K.MISUTA: "Expression of highly polysialylated neural cell adhesion molecule in pancreatic cancer neural invasive lesion"CANCER LETTERS. 137. 201-207 (1999)

K.KAMEDA、K.MISUTA：“胰腺癌神经浸润性病变中高度聚唾液酸化的神经细胞粘附分子的表达”癌症信件。