Expression and Function of Extracellular Matrix expressed in Cholangiocarcinoma.

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Immunohistochemical study revealed that collagens type I, III, V and XII were expressed by fibroblasts in cholangiocarcinoma and collagens type V, IX, XII, XIV and XVI were expressed by cancer cells of cholangiocarcinoma. In addition, Immunohistochemical study revealed that DDR1 and Integrin beta1 receptor, which are collagen receptor, and focal adhesion kinase (FAK), an integrin downstrem molecule, were expressed by cancer cells as well as fibroblasts in cholangiocarcinoma tissues. They were also expressed by cholangiocarcinoma cell lines and fibroblasts isolated from cholangiocarcinoma tissues. In culture experiments, FAK specific inhibitor suppressed cell growth and cell invaison ability of RBE cells, SSP-25 cells, cell lines of cholangiocarcinoma, and fibroblasts. Taken together, FAK may be an important molecule to regulate matrix-FAK signaling dependant cancer behavors.