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Is it possible to develop radical treatment of cancer based on cancer stem cell theory?

Is it possible to develop radical treatment of cancer based on cancer stem cell theory?
基于癌症干细胞理论是否有可能开发出癌症根治性治疗方法？
批准号：
20591634
负责人：
TAKAMORI Hiroshi
金额：
$3.0万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2010
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591634/
关键词：
がん幹細胞ポリコーム群蛋白Bmi-1EZH-2膵癌膵管内乳頭状粘液腫瘍発癌転移制御がん根治治療膵がん正常幹細胞miR-101消化器がん

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中文摘要
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英文摘要
Bmi-1, which is one of the polycomb group protein, is expressed in the nucleus of the cancer cells, but is not expressed in stroma cells in the pancreatic cancer tissues. There was no specific characteristic of expression of Bmi-1, that is, Bmi-1 distributes in the tumor tissue diffusely. There was no statistical significance of prognosis between Bmi-1 expression cases and a non-expression case of Bmi-1. EZH-2, which is also one of the polycomb group protein, is not expressed in normal pancreatic duct and adenoma, but is expressed in cancer cells. It indicated that EZH-2 might be contributed to carcinogenesis of pancreatic cancer.
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Serine Protease Inhibitor Kazal Type 1 Promotes Proliferation of Pancreatic Cancer Cells through the Epidermal Growth Factor Receptor
DOI： 10.1158/1541-7786.mcr-08-0567
发表时间： 2009-09-01
期刊： MOLECULAR CANCER RESEARCH
影响因子： 5.2
作者： [Ozaki, Nobuyuki, Ohmuraya, Masaki, Yamamura, Ken-ichi]
通讯作者： Yamamura, Ken-ichi
Small solid pseudopapillary tumor of the pancreas in a 32-year-old man: Report of a case
DOI： 10.1007/s00595-009-4139-x
发表时间： 2010-08-01
期刊： SURGERY TODAY
影响因子： 2.5
作者： [Mima, Kosuke, Hirota, Masahiko, Baba, Hideo]
通讯作者： Baba, Hideo
Treatment results of FOLFOX chemotherapy before surgery for lymph node metastasis of advanced colorectal cancer with synchronous liver metastasis: the status of LN metastasis and vessel invasions at the primary site in patients who responded to FOLFOX
DOI： 10.1007/s10147-009-0013-5
发表时间： 2010-01
期刊： International Journal of Clinical Oncology
影响因子： 3.3
作者： [H. Sawayama;N. Hayashi;Shinobu Honda;Y. Baba;E. Toyama;Masayuki Watanabe;H. Takamori;T. Beppu;H. Baba]
通讯作者： H. Sawayama;N. Hayashi;Shinobu Honda;Y. Baba;E. Toyama;Masayuki Watanabe;H. Takamori;T. Beppu;H. Baba
FOLFOX enables high resectability and excellent prognosis for initially unresectable colorectal liver metastases.
FOLFOX 对于最初不可切除的结直肠肝转移瘤具有较高的可切除性和良好的预后。
DOI： --
发表时间： 2010
期刊： Anticancer Res. 30
影响因子： --
作者： [T.Beppu, N.Hayashi, T.Masuda, H.Komori, K.Horino, H.Hayashi, H.Okabe, Y.Baba, K.Kinoshita, C.Akira, M.Watanebe, H.Takamori, H.Baba.]
通讯作者： H.Baba.
共 136 条
    Analysis of the interaction between pancreatic stromal cells and adenocarcinoma via complement component 5a receptor
    • 批准号：
      18K08623
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $2.91万
    • 财政年份：
      2018
    • 负责人：
      TAKAMORI Hiroshi
    • 依托单位：
      Kumamoto University
    Clinical implication of Farnesoid-X-receptor agonist in liver regeneration after hepatectomy
    • 批准号：
      26462047
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.16万
    • 财政年份：
      2014
    • 负责人：
      TAKAMORI Hiroshi
    • 依托单位：
      Kumamoto University
    Investigation into epigenetic regulatory mechanism by microRNA in carcinogenesis
    • 批准号：
      23592015
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.24万
    • 财政年份：
      2011
    • 负责人：
      TAKAMORI Hiroshi
    • 依托单位：
      Kumamoto University
    System Analytic Approach to Financial Technology, Management and Governance
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