Investigation of differentiation of extrapancreatic stem cells to pancreatic β-cells

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The differentiation of stem cells to pancreatic ss-cells, which produce and secrete insulin, is confirmed by several experimental studies, and the transplantation of such differentiated cells into patients with diabetes is actively studied. Such stem cell therapy will therefore require a large number of differentiated cells to obtain sufficient curative effects. We demonstrated that spheroid formation and suspension culture of ss-cells enhanced the insulin secretory capacity and sensitivity of ss-cells to sulfonylurea drugs such as tolbutamide via functional changes in insulin-secretion-related molecules.