Microarray analysis of carotid plaques on the basis of Agatston scores

重建颈动脉狭窄患者的多层螺旋CT图像，计算Agatston评分(AS)。从颈动脉斑块中提取mRNAs后进行基因尖端表达谱分析。在根据AS100分类的样本比较后，炎症相关基因的表达强度注意到两倍以上的差异。重度钙化斑块中NFAT、ADAMTS、ANGPTL4表达上调，Angptl7表达下调。

We reconstructed MDCT images of the patients of carotid stenoses and calculated Agatston scores (AS). Gene tip expression array analysis was performed after extraction of mRNAs from carotid plaques. Over double difference was noted for the intensity of the expression for inflammation-related genes after comparison of specimens classified based on AS100. Upregulation of NFAT, ADAMTS, Angptl4 and downregulation of Angptl7 were observed in severely calcified plaques.