X-ray dark field imaging of human articular cartilage: Possible clinical application to orthopedic surgery

人体关节软骨的 X 射线暗场成像：骨科手术的可能临床应用

• 批准号: 20591781
• 负责人: KUNISADA Toshiyuki
• 金额: $ 2.83万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591781/
• 关键词: 関節軟骨; 放射光; 医学利用; 画像診断; X線画像; 暗視野法; 屈折コントラスト

We developed a novel type of X-ray dark field imaging (DFI). We examined a disarticulated distal femur and a shoulder joint with surrounding soft tissue and skin, both excised from a human cadaver. Articular cartilage of the disarticulated distal femur was obvious on DFI, but not on standard X-ray images. Furthermore, DFI allowed visualization in situ of articular cartilage of the shoulder while covered with soft tissue and skin. The gross appearance of the articular cartilage on the dissected section of the proximal humerus was identical to the cartilage shown on the DFI image. These results suggested that DFI could provide a clinically accurate method of assessing articular cartilage. Hence, DFI would be a useful imaging tool for diagnosing joint disease such as osteoarthritis.

我们开发了一种新型的x射线暗场成像（DFI）。我们检查了从人体尸体上切除的脱臼的股骨远端和肩关节及其周围的软组织和皮肤。脱臼股骨远端关节软骨在DFI上很明显，但在标准x线图像上不明显。此外，DFI允许在覆盖软组织和皮肤的情况下原位显示肩关节软骨。肱骨近端解剖段关节软骨的大体外观与DFI图像上显示的软骨相同。这些结果表明，DFI可以提供临床准确的评估关节软骨的方法。因此，DFI将是诊断关节疾病（如骨关节炎）的有用成像工具。

项目成果

Imaging of Articular Cartilage : Clinical Application to Joint Disease

关节软骨成像：在关节疾病中的临床应用

• 发表时间: 2010
• 作者: Yui;Yoshihiro;国定俊之;国定俊之
• 通讯作者: 国定俊之

Thallium-201 Scintigraphy Is an Effective Diagnostic Modality to Distinguish Malignant From Benign Soft-Tissue Tumors

• DOI: 10.1097/rlu.0b013e3182177407
• 发表时间: 2011-11-01
• 期刊: CLINICAL NUCLEAR MEDICINE
• 影响因子: 10.6
• 作者: Kawakami, Naoaki;Kunisada, Toshiyuki;Ozaki, Toshifumi
• 通讯作者: Ozaki, Toshifumi

Chondrosarcoma and peroxisome proliferator-activated receptor.

软骨肉瘤和过氧化物酶体增殖物激活受体。

• DOI: 10.1155/2008/250568
• 发表时间: 2008
• 期刊: PPAR research
• 影响因子: 2.9
• 作者: Nishida K;Kunisada T;Shen ZN;Kadota Y;Hashizume K;Ozaki T
• 通讯作者: Ozaki T

Refraction-based 2D, 2.5D and 3D medical imaging: stepping forward to a clinical trial.

基于折射的 2D、2.5D 和 3D 医学成像：迈向临床试验。

• DOI: 10.1016/j.ejrad.2008.04.033
• 发表时间: 2008
• 期刊: European journal of radiology
• 影响因子: 3.3
• 作者: M. Ando;H. Bando;T. Endo;S. Ichihara;E. Hashimoto;K. Hyodo;T. Kunisada;Gang Li;A. Maksimenko;K. Mori;D. Shimao;H. Sugiyama;T. Yuasa;E. Ueno
• 通讯作者: E. Ueno

Photodynamic therapy with ATX-S10•Na(II) inhibits synovial sarcoma cell growth

• DOI: 10.1007/s11999-008-0284-6
• 发表时间: 2008-07-01
• 期刊: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
• 影响因子: 4.2
• 作者: Takeda, Ken;Kunisada, Toshiyuki;Ozaki, Toshifumi
• 通讯作者: Ozaki, Toshifumi