A study on genes that associated with response to biologic agents.

与生物制剂反应相关的基因的研究。

• 批准号: 20591791
• 负责人: MOMOHARA Shigeki
• 金额: $ 3.08万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591791/
• 关键词: リウマチ病学; 関節リウマチ; 生物学的製剤

We tried to detect the genes that associated with response to biologic agents using disease-associated polymorphisms as candidate, and found that a SNP, rs10919563, on PTPRC gene is significantly associated with response to biologic agents (P<0.05). Since the SNP is also known as anti-TNF-α therapy response polymorphism in Caucasian, it seems to be a reliable result.

我们试图以疾病相关多态作为候选基因来检测与生物制剂应答相关的基因，发现PTPRC基因上的一个单核苷酸多态rs10919563与生物制剂应答显著相关(P&lt；0.05)。由于SNP在高加索人群中也被称为抗肿瘤坏死因子-α治疗反应多态性，这似乎是一个可靠的结果。

项目成果

Associated factors for falls and fear of falling in Japanese patients with rheumatoid arthritis

• DOI: 10.1007/s10067-009-1229-5
• 发表时间: 2009-11-01
• 期刊: CLINICAL RHEUMATOLOGY
• 影响因子: 3.4
• 作者: Furuya, Takefumi;Yamagiwa, Kiyotaka;Yamanaka, Hisashi
• 通讯作者: Yamanaka, Hisashi

Comparison of the second and third generation anti-cyclic citrullinated peptide antibody assays in the diagnosis of Japanese patients with rheumatoid arthritis

• DOI: 10.1007/s00296-009-1336-2
• 发表时间: 2011-05-01
• 期刊: RHEUMATOLOGY INTERNATIONAL
• 影响因子: 4
• 作者: Shidara, Kumi;Inoue, Eisuke;Yamanaka, Hisashi
• 通讯作者: Yamanaka, Hisashi

Efficacy and tolerability of tocilizumab in rheumatoid arthritis patients seen in daily clinical practice in Japan: results from a retrospective study (REACTION study).

• DOI: 10.1007/s10165-010-0366-7
• 发表时间: 2011-04
• 期刊: MODERN RHEUMATOLOGY
• 影响因子: 2.2
• 作者: Yamanaka, Hisashi;Tanaka, Yoshiya;Inoue, Eisuke;Hoshi, Daisuke;Momohara, Shigeki;Hanami, Kentaro;Yunoue, Naoki;Saito, Kazuyoshi;Amano, Kouichi;Kameda, Hideto;Takeuchi, Tsutomu
• 通讯作者: Takeuchi, Tsutomu

Infusion reaction to infliximab in a patient with rheumatoid arthritis after discontinuation over 1 year and readministration

类风湿性关节炎患者停药一年以上并重新给药后出现英夫利昔单抗输注反应

• 发表时间: 2008
• 期刊: J Rheumatol 35
• 作者: Tsukahara;et.al.
• 通讯作者: et.al.

A polymorphism in the gene encoding the Fcgamma IIIA receptor is a possible genetic marker to predict the primary response to infliximab in Japanese patients with rheumatoid arthritis

编码 Fcgamma IIIA 受体的基因多态性可能是预测日本类风湿关节炎患者对英夫利昔单抗主要反应的遗传标记

• 发表时间: 2008
• 期刊: Ann Rheum Dis 67
• 作者: Tsukahara;et.al.
• 通讯作者: et.al.