Bladder reconstruction by autologous bone-marrow-derived mesenchymal stem cell

自体骨髓间充质干细胞重建膀胱

• 批准号: 20591877
• 负责人: ISHIZUKA Osamu
• 金额: $ 3万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591877/
• 关键词: 骨髄幹細胞; 再生医療; 膀胱; 移植・再生医療; 再生医学; 細胞・組織; 生体機能利用; 脳神経疾患

From the clinical point of view, urethral sphincter reconstruction is important to prevent urinary incontinence in the field of bladder reconstruction. At first, we could culture and proliferate the bone-marrow-derived mesenchymal stem cells derived from the femur of rabbit. The cultured stem cells were implanted into the injured urethral sphincter, and we could found the reconstruction of the urethral sphincter by histological methods (immunohistochemistry, RT-PCR method) and functional study.

从临床角度看，在膀胱重建领域，尿路括约肌重建术对于预防尿失禁具有重要意义。首先，我们可以培养和扩增兔股骨骨髓间充质干细胞。将培养的干细胞移植到损伤的尿路括约肌中，通过组织学方法(免疫组织化学、RT-PCR方法)和功能研究，可以找到重建的尿路括约肌。

项目成果

Implantation of human amniotic mesenchymal cells promotes morphological and functional recovery of the freeze-injured mouse urinary bladder.

人羊膜间充质细胞的植入可促进冻伤小鼠膀胱的形态和功能恢复。

• 发表时间: 2010
• 作者: O Minagawa;T.;Imamura;T.;Aizawa;N.;Ishizuka;O.;Igawa;Y.;Nishizawa;O.
• 通讯作者: O.

Implantation of mouse bone marrow cells reconstructs layered smooth muscle structures in injured urinary bladder.

小鼠骨髓细胞的植入重建了受损膀胱中的分层平滑肌结构。

• 发表时间: 2008
• 期刊: Cell transplantation 17
• 作者: Imamura;T.;Kinebuchi;Y.;Ishizuka;O.;Seki;S.;Igawa;Y.;Nishizawa;O.
• 通讯作者: O.

Possibility of regeneration of urinary bladder and urethral sphincter by own bone marrow cell.

通过自身骨髓细胞再生膀胱和尿道括约肌的可能性。

• 发表时间: 2009
• 作者: Ishizuka;O.
• 通讯作者: O.

Autologous bone-marrow-derived mesenchymal stem cell transplantation into injured rat urethral sphincter

• DOI: 10.1111/j.1442-2042.2010.02471.x
• 发表时间: 2010-04-01
• 期刊: INTERNATIONAL JOURNAL OF UROLOGY
• 影响因子: 2.6
• 作者: Kinebuchi, Yoshiaki;Aizawa, Naoki;Nishizawa, Osamu
• 通讯作者: Nishizawa, Osamu

Rat Bladders Augmented with a Novel Bovine Pericardium-Derived Biomaterial Reconstruct Functional Tissue Structures.

用新型牛心包衍生生物材料增强大鼠膀胱，重建功能组织结构。

• 发表时间: 2009
• 期刊: LUTS (掲載決定)
• 作者: Yuji Mimura;Tetsuya Imamura;(他4名)
• 通讯作者: (他4名)