Study on new treatment strategy for bladder storage dysfunction
Study on new treatment strategy for bladder storage dysfunction
批准号:
20591875
负责人:
IGAWA Yasuhiko
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Electrophysiological investigation in the rat revealed that beta3-AR agonists and activation of L-arginine/NO inhibit mechanosensitive afferent nerve activities primarily originating from the bladder in response to bladder distension as well as increased afferent nerve activities induced by intravesical instillation of PGE_2 and acrolein, respectively. Freeze-injured mouse bladders implanted with human amniotic mesenchymal cells recovered morphology and function faster than control-injected bladders. CXCL10 in the bladder urothelium and urine increased in ulcer type interstitial cystitis, suggesting its possible use as a biomarker.
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DOI:
10.1016/j.eururo.2009.12.031
发表时间:
2010-08-01
期刊:
EUROPEAN UROLOGY
影响因子:
23.4
作者:
[Minagawa, Tomonori, Imamura, Tetsuya, Nishizawa, Osamu]
通讯作者:
Nishizawa, Osamu
DOI:
10.1016/j.juro.2009.07.012
发表时间:
2009-11-01
期刊:
JOURNAL OF UROLOGY
影响因子:
6.6
作者:
[Iijima, Kazuyoshi, Igawa, Yasuhiko, Wyndaele, Jean-Jacques]
通讯作者:
Wyndaele, Jean-Jacques
神経因性膀胱の治療
神经源性膀胱的治疗
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Yoshiji Miwa, Nobuyuki Oyama, Hironobu Akino, Osamu Yokoyama, 井川靖彦]
通讯作者:
井川靖彦
Saline loading caused the change of the expression of A1-adrenoceptor subtypes and angiotensin II type1 receptors in the prostate of spontaneously hypertensive rats.
盐水负荷引起自发性高血压大鼠前列腺A1-肾上腺素受体亚型和血管紧张素II-1型受体表达的变化。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ishizuka O, Nakayama T, Imamura T, Kurizaki Y, Igawa Y, Nishizawa O, Andersson K]
通讯作者:
Andersson K
Relation between expression of A1-adrenoceptor mRNAs in bladder mucosa and urodynamic findings in men with lower urinary tract symptoms.
具有下尿路症状的男性膀胱粘膜中 A1-肾上腺素受体 mRNA 的表达与尿动力学结果之间的关系。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kurizaki Y, Ishizuka O, Imamura T, Ichino M, Ogawa T, Igawa Y, Nishizawa O, Andersson K.]
通讯作者:
Andersson K.
共 42 条
Development of novel pharmacological treatment of lower urinary tract dysfunction by targeting bladder afferent transduction
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批准号:23592358
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2011
-
负责人:IGAWA Yasuhiko
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依托单位:
Development of new therapy for bladder dysfunction:Combined approaches of phamiacology and tissue engineering
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批准号:18591745
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.53万
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财政年份:2006
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负责人:IGAWA Yasuhiko
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依托单位:
Development of new drugs targeting at the urothelial-afferent neurotransduction system for bladder storage dysfunction
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批准号:16591589
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
-
财政年份:2004
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负责人:IGAWA Yasuhiko
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依托单位:
Development of new drugs for bladder storage dysfunction targeting beta3 adrenoceptors and bladder afferent nerves
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批准号:13671641
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:2001
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负责人:IGAWA Yasuhiko
-
依托单位:
The pathophysiology of the overactive bladder associated with spinal cord injury : Involvement of capsaicin-sensitive primary bladder afferent nerves
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批准号:11671545
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1999
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负责人:IGAWA Yasuhiko
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依托单位:
The mechanism of bladder overactivity associated with spinal cord injury : Involvement of plasticity of bladder afferent nerves and nerve growth factors
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批准号:09671621
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1997
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负责人:IGAWA Yasuhiko
-
依托单位: