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Study on new treatment strategy for bladder storage dysfunction

Study on new treatment strategy for bladder storage dysfunction
膀胱储存功能障碍治疗新策略的研究
批准号:
20591875
负责人:
IGAWA Yasuhiko
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

IGAWA Yasuhiko的其他基金

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中文摘要
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英文摘要
Electrophysiological investigation in the rat revealed that beta3-AR agonists and activation of L-arginine/NO inhibit mechanosensitive afferent nerve activities primarily originating from the bladder in response to bladder distension as well as increased afferent nerve activities induced by intravesical instillation of PGE_2 and acrolein, respectively. Freeze-injured mouse bladders implanted with human amniotic mesenchymal cells recovered morphology and function faster than control-injected bladders. CXCL10 in the bladder urothelium and urine increased in ulcer type interstitial cystitis, suggesting its possible use as a biomarker.
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DOI: 10.1016/j.eururo.2009.12.031
发表时间: 2010-08-01
期刊: EUROPEAN UROLOGY
影响因子: 23.4
作者: [Minagawa, Tomonori, Imamura, Tetsuya, Nishizawa, Osamu]
通讯作者: Nishizawa, Osamu
DOI: 10.1016/j.juro.2009.07.012
发表时间: 2009-11-01
期刊: JOURNAL OF UROLOGY
影响因子: 6.6
作者: [Iijima, Kazuyoshi, Igawa, Yasuhiko, Wyndaele, Jean-Jacques]
通讯作者: Wyndaele, Jean-Jacques
神経因性膀胱の治療
神经源性膀胱的治疗
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Yoshiji Miwa, Nobuyuki Oyama, Hironobu Akino, Osamu Yokoyama, 井川靖彦]
通讯作者: 井川靖彦
Saline loading caused the change of the expression of A1-adrenoceptor subtypes and angiotensin II type1 receptors in the prostate of spontaneously hypertensive rats.
盐水负荷引起自发性高血压大鼠前列腺A1-肾上腺素受体亚型和血管紧张素II-1型受体表达的变化。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Ishizuka O, Nakayama T, Imamura T, Kurizaki Y, Igawa Y, Nishizawa O, Andersson K]
通讯作者: Andersson K
42
    Development of novel pharmacological treatment of lower urinary tract dysfunction by targeting bladder afferent transduction
    • 批准号:
      23592358
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.24万
    • 财政年份:
      2011
    • 负责人:
      IGAWA Yasuhiko
    • 依托单位:
    Development of new therapy for bladder dysfunction:Combined approaches of phamiacology and tissue engineering
    • 批准号:
      18591745
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.53万
    • 财政年份:
      2006
    • 负责人:
      IGAWA Yasuhiko
    • 依托单位:
    Development of new drugs targeting at the urothelial-afferent neurotransduction system for bladder storage dysfunction
    • 批准号:
      16591589
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.05万
    • 财政年份:
      2004
    • 负责人:
      IGAWA Yasuhiko
    • 依托单位:
    Development of new drugs for bladder storage dysfunction targeting beta3 adrenoceptors and bladder afferent nerves
    • 批准号:
      13671641
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.86万
    • 财政年份:
      2001
    • 负责人:
      IGAWA Yasuhiko
    • 依托单位: