Influence on allergic rhinitis of the endocrine disruptor

我用人外周血单个核细胞(PBMC)IgE生产培养系统检测了内分泌干扰物对变应性鼻炎的影响。很明显，尽管不同的物质有不同，内分泌干扰物被证明是一种低剂量的促进IgE产生的效应。此外，我了解到，个人的反应是不同的。我接受了关于环境化学物质代谢的有意义的SNP与成年雪松花粉症发病的基因CYP1A1的相关性。血小板衍生内皮细胞生长因子(PD-ECGF)，又称胸苷磷酸化酶(TP)，是一种强有力的血管生成因子。我们的结果提示TP参与促进IgE的产生，并提示胸苷磷酸化酶抑制剂(TPI)可能是治疗IgE相关变态反应性疾病的新策略。

I examined it with IgE production culture system of human peripheral blood mononuclear cells (PBMC) about the influence on allergic rhinitis of the endocrine disruptor. It became clear, although there is the difference by a material ,that the endocrine disruptor was proved IgE production enhancement as a low-dose effect. In addition, I understood that there was individual difference in the reaction. I accepted a meaningful correlation of SNP and adult cedar pollinosis onset of gene CYP1A1 about environmental chemical substance metabolism. Platelet-derived endothelial cell growth factor (PD-ECGF), also known as thymidine phosphorylase (TP) is a potent angiogenic factor. Our results suggest TP involvement in the enhancement of IgE production and suggest that Thymidine phosphorylase inhibitor (TPI) might be a novel strategy against IgE-related allergic disease.