Influence on allergic rhinitis of the endocrine disruptor

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I examined it with IgE production culture system of human peripheral blood mononuclear cells (PBMC) about the influence on allergic rhinitis of the endocrine disruptor. It became clear, although there is the difference by a material ,that the endocrine disruptor was proved IgE production enhancement as a low-dose effect. In addition, I understood that there was individual difference in the reaction. I accepted a meaningful correlation of SNP and adult cedar pollinosis onset of gene CYP1A1 about environmental chemical substance metabolism. Platelet-derived endothelial cell growth factor (PD-ECGF), also known as thymidine phosphorylase (TP) is a potent angiogenic factor. Our results suggest TP involvement in the enhancement of IgE production and suggest that Thymidine phosphorylase inhibitor (TPI) might be a novel strategy against IgE-related allergic disease.