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Roles of stromal cells in the survival, growth, differentiation, migration of laryngeal carcinoma-derived cancer stem cells and its mechanisms

Roles of stromal cells in the survival, growth, differentiation, migration of laryngeal carcinoma-derived cancer stem cells and its mechanisms
基质细胞在喉癌干细胞存活、生长、分化、迁移中的作用及其机制
批准号:
20592023
负责人:
TODA Shuji
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Stromal fibroblasts promote the survival, self-renewal and cancer cell production of cancer stem cells under cancer stem cell-fibroblast interaction, while both adipocytes and adipose tissues tend to inhibit those of the cancer stem cells. Adipose tissue-derived free fatty acid, palmitate, tends to promote the apoptosis of cancer stem cells. Finally, the stromal-cancer stem cell interaction does not induce the significant changes ofadipokine production and gene expression.
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DOI: 10.1111/j.1440-1827.2010.02511.x
发表时间: 2010-04
期刊: Pathology International
影响因子: 2.2
作者: [K. Uchihashi;S. Aoki;M. Shigematsu;Noriyuki Kamochi;Emiko Sonoda;H. Soejima;K. Fukudome;H. Sugihara;T. Hotokebuchi;S. Toda]
通讯作者: K. Uchihashi;S. Aoki;M. Shigematsu;Noriyuki Kamochi;Emiko Sonoda;H. Soejima;K. Fukudome;H. Sugihara;T. Hotokebuchi;S. Toda
Non-skin mesenchymal cell types support epidermal regeneration in a mesenchymal stem cell or myofibroblast phenotype-independent manner.
非皮肤间充质细胞类型以间充质干细胞或肌成纤维细胞表型独立的方式支持表皮再生。
DOI: --
发表时间: 2009
期刊: Pathol Int 59
影响因子: --
作者: [Aoki S, Takezawa T, Uchihashi K, Sugihara H, Toda S.]
通讯作者: Toda S.
DOI: 10.3747/pdi.2010.00157
发表时间: 2011-07-01
期刊: PERITONEAL DIALYSIS INTERNATIONAL
影响因子: 2.8
作者: [Aoki, Shigehisa, Makino, Junichi, Toda, Shuji]
通讯作者: Toda, Shuji
The air liquid-interface, a skin microenvironment, promotes growth of melanoma cells, but not their apoptosis and invasion, through activation of mitogen-activated protein kinase
气液界面(皮肤微环境)通过丝裂原激活蛋白激酶的激活促进黑色素瘤细胞的生长,但不促进其凋亡和侵袭
DOI: --
发表时间: 2010
期刊: Acta Histochem Cytochem
影响因子: --
作者: [Yee CH, Aoki S, Uchihashi K, Matsunobu A,Yamasaki F, et.al.]
通讯作者: et.al.
26
    Roles of adipose tissue in survival, differentiation and lipotoxicity of cardiomyocytes
    • 批准号:
      23591050
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2011
    • 负责人:
      TODA Shuji
    • 依托单位:
    Arole of cell membrane microdomains in air-liquid interface-induced invasive growth of laryngeal carcinoma cells
    • 批准号:
      18591871
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.13万
    • 财政年份:
      2006
    • 负责人:
      TODA Shuji
    • 依托单位:
    Air-liquid interface microenvironment and its effects on growth and differentiation of mucosal epithelial cells of alimentary tract : its possible roles as a luminal factor
    • 批准号:
      16590604
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.47万
    • 财政年份:
      2004
    • 负责人:
      TODA Shuji
    • 依托单位:
    海外基金