Roles of stromal cells in the survival, growth, differentiation, migration of laryngeal carcinoma-derived cancer stem cells and its mechanisms

基质细胞在喉癌干细胞存活、生长、分化、迁移中的作用及其机制

• 批准号: 20592023
• 负责人: TODA Shuji
• 金额: $ 2.91万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592023/
• 关键词: 喉頭癌; 癌幹細胞; 線維芽細胞; 脂肪細胞; 増殖; アポトーシス; 遊走; 浸潤

Stromal fibroblasts promote the survival, self-renewal and cancer cell production of cancer stem cells under cancer stem cell-fibroblast interaction, while both adipocytes and adipose tissues tend to inhibit those of the cancer stem cells. Adipose tissue-derived free fatty acid, palmitate, tends to promote the apoptosis of cancer stem cells. Finally, the stromal-cancer stem cell interaction does not induce the significant changes ofadipokine production and gene expression.

基质成纤维细胞在癌干细胞-成纤维细胞相互作用下促进癌干细胞的存活、自我更新和癌细胞产生，而脂肪细胞和脂肪组织倾向于抑制癌干细胞的那些。脂肪组织来源的游离脂肪酸棕榈酸酯倾向于促进癌症干细胞的凋亡。最后，间质-肿瘤干细胞相互作用不诱导fadipokine产生和基因表达的显著变化。

项目成果

Organotypic culture of human bone marrow adipose tissue

• DOI: 10.1111/j.1440-1827.2010.02511.x
• 发表时间: 2010-04
• 期刊: Pathology International
• 影响因子: 2.2
• 作者: K. Uchihashi;S. Aoki;M. Shigematsu;Noriyuki Kamochi;Emiko Sonoda;H. Soejima;K. Fukudome;H. Sugihara;T. Hotokebuchi;S. Toda

Non-skin mesenchymal cell types support epidermal regeneration in a mesenchymal stem cell or myofibroblast phenotype-independent manner.

非皮肤间充质细胞类型以间充质干细胞或肌成纤维细胞表型独立的方式支持表皮再生。

• 发表时间: 2009
• 期刊: Pathol Int 59
• 作者: Aoki S;Takezawa T;Uchihashi K;Sugihara H;Toda S.
• 通讯作者: Toda S.

FLUID FLOW STRESS AFFECTS PERITONEAL CELL KINETICS: POSSIBLE PATHOGENESIS OF PERITONEAL FIBROSIS

• DOI: 10.3747/pdi.2010.00157
• 发表时间: 2011-07-01
• 期刊: PERITONEAL DIALYSIS INTERNATIONAL
• 影响因子: 2.8
• 作者: Aoki, Shigehisa;Makino, Junichi;Toda, Shuji
• 通讯作者: Toda, Shuji

The air liquid-interface, a skin microenvironment, promotes growth of melanoma cells, but not their apoptosis and invasion, through activation of mitogen-activated protein kinase

气液界面（皮肤微环境）通过丝裂原激活蛋白激酶的激活促进黑色素瘤细胞的生长，但不促进其凋亡和侵袭

• 发表时间: 2010
• 期刊: Acta Histochem Cytochem
• 作者: Yee CH;Aoki S;Uchihashi K;Matsunobu A,Yamasaki F;et.al.
• 通讯作者: et.al.

Adipose tissue-organotypic culture as a promising model for studying adipose tissue biology and regeneration

脂肪组织器官培养作为研究脂肪组织生物学和再生的有前途的模型

• 发表时间: 2009
• 期刊: Organogenesis 5
• 作者: Shuji Toda;et al.
• 通讯作者: et al.