TPN administration lead to alteration of hepatocyte cell cycle and metabolic abnormalities in the mouse model with intestinal failure

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The aim of this study was to test the hypothesis that PN administration in the mouse models with intestinal failure would lead to alteration of hepatocyte cell cycle and metabolic abnormalities of glucose and lipids and subsequently lead to an altered abundance of adipocytokines and their related gene expression in a rat model. This study also investigated whether some or all of these PN-associated metabolic abnormalities are related to parenteral lipid administration. The study shows that PN led to specific alterations in the abundance of adipocytokines and PPARs. These changes give critical insight into many of the metabolic derangements in lipid metabolism, which patients may experience with PN.