Is a novel prognostic marker for post cardiac arrest brain injury beneficial or detrimental?

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Molecular structures, functions, and cellular components of a novel prognostic marker for post cardiac arrest brain injury were investigated. The marker protein was expressed and localized in the cytoplasm and/or nucleus of cultured cells under the physiological conditions. In contrast, the marker protein was released into the extracellular space, and underwent a unique post-translational modification under the stress conditions. Because we were not able to establish a stable cell line expressing the marker protein constitutively, it might be possible that the increased expression of the marker protein followed by the release into the extracellular space could be detrimental to the clinical course of post-cardiac arrest brain injury