Application of calcium phosphate cement containing bioactive glasses for endodontic therapy

含生物活性玻璃的磷酸钙骨水泥在牙髓治疗中的应用

• 批准号: 20592248
• 负责人: IZUMI Toshio
• 金额: $ 2.25万
• 依托单位: Fukuoka Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592248/
• 关键词: リン酸カルシウムセメント; bioactive glass; 覆髄材; 骨補填材; Bioactive glass; apoptosis; 大食球

The dentin bridge formation was observed when a new calcium phosphate cement (CPC) that contained bioactive glasses was used as a pulp capping agent. And there was no significant difference in the ability of dentin bridge formation between the new CPC and a calcium hydroxide. Some apoptic cells were observed in the pulp during dentin bridge formation. It was suggested that about 60% of apoptic cells should be monocytes/macrophages, which contained TUNEL+ nucleus, and the rest should be pulp cells. The new CPC did not make a significant difference in the new bone formation compared with hydroxyapatite as a bone grafting material.

当使用含有生物活性玻璃的新型磷酸钙水泥（CPC）作为牙髓封盖剂时，观察到牙本质桥的形成。新CPC与氢氧化钙在牙本质桥的形成能力上无显著差异。牙本质桥形成过程中，在牙髓内可见一些凋亡细胞。提示凋亡细胞约60%为单核/巨噬细胞，含有TUNEL+核，其余为髓细胞。与羟基磷灰石作为植骨材料相比，新CPC在新骨形成方面没有显著差异。

项目成果

Pro-inflammatory Cytokines Induce Suppressor of Cytokine Signaling-3 in Human Periodontal Ligament Cells

• DOI: 10.1016/j.joen.2010.02.027
• 发表时间: 2010-06-01
• 期刊: JOURNAL OF ENDODONTICS
• 影响因子: 4.2
• 作者: Fukushima, Akie;Kajiya, Hiroshi;Anan, Hisashi
• 通讯作者: Anan, Hisashi

歯髄創傷治癒に及ぼすエムドゲインゲルの影響

Emdogain凝胶对牙髓伤口愈合的影响

• 发表时间: 2010
• 期刊: 福岡歯科大学学会雑誌 36巻
• 作者: 阿南壽、松本典祥、泉利雄;他
• 通讯作者: 他

PTHrP Induces Notch Signaling in Periodontal Ligament Cells

• DOI: 10.1177/0022034509337899
• 发表时间: 2009-06-01
• 期刊: JOURNAL OF DENTAL RESEARCH
• 影响因子: 7.6
• 作者: Nakao, A.;Kajiya, H.;Okabe, K.
• 通讯作者: Okabe, K.