Development of new bone filling materials using Sr-containing bioactive glasses

锶（Sr）已被证明在体内促进骨形成，被用作抗骨质疏松的口服药物。生物活性玻璃通过在其表面形成类骨羟基磷灰石层与骨发生化学键合，可作为骨替代材料。 我们制备了含锶生物活性玻璃颗粒的试品，并表明它们可以促进大鼠颅骨缺损的骨再生。将酸与含锶玻璃颗粒混合制成硬化骨水泥浆体，用于致密填充大鼠颅骨缺损。当使用聚谷氨酸时，骨水泥浆容易从缺损处流出，但建议骨水泥浆应促进新骨形成。

Strontium (Sr) that has been proved to promote bone formation in vivo is used as an anti-osteoporotic oral drug. The bioactive glass can bond chemically to bone through formation of bone-like hydroxyapatite layer on its surface, and is used as a bone substitute material. We prepared trial products of Sr-containing bioactive glass particles, and it was suggested that they could promote bone regeneration in rat calvarial defects. There may be an association with the controlled release of Sr to the bone tissue, which occured by dissolution of the glass particles.Hardened cement pastes were made by mixing acid and the Sr-containing glass particles in order to fill densely the rat calvarial defects. When polyglutamic acid was used, a cement paste was easy to flow out of the defects, but it was suggested that the paste should promote formation of new bone.