Examination of effectiveness of Bioactive glass for endodontic treatment

生物活性玻璃用于牙髓治疗的有效性检查

• 批准号: 15592038
• 负责人: IZUMI Toshio
• 金额: $ 1.41万
• 依托单位: Fukuoka Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15592038/
• 关键词: Bioactive glass; Pulp capping; Periapical lesion; Perforation; Endodontics; 覆髄; 直接覆髄材

We have examined tissue reactions to Bioactive glass (BAG) in 3 situations associated with endodontic treatments.Experiment I ; BAG was applied to exposed dental pulp, and a dentin bridge formation was observed 4 weeks after it. The dentin bridge was porous, and it was assumed that the pores would be associated with the remnant granulation tissues between the BAG particles. Some odontoblasts lining along the dentin bridge had swollen cell bodies showing their high activity.Experiment II ; BAG was applied into the root canals with the experimentally induced periapical abscess. It was impossible for BAG to r fill the apical space, and to react to the periapical lesions. The paste-like mixture of BAG and some material would be handled more easily into the canals.Experiment III ; BAG was applied to the experimentally perforated area at the pulp floor, and after 4 weeks, many activated osteoblasts were observed, and it was noted that the area was filled close with calcified tissue, suggesting its high osteoconductivity. Some foreign-body giant cells, however, and small amount of granulation tissue were seen in part, and the plugged area would be in danger of poor blockage. It would be expected that the application of a mixture of BAG and some cement might show better results.

实验一：将生物活性玻璃（BAG）应用于暴露的牙髓，4周后观察到牙本质桥的形成，牙本质桥是多孔的，推测这些孔与BAG颗粒之间残留的肉芽组织有关。一些成牙本质细胞衬沿着牙本质桥有肿胀的细胞体显示其高活性。实验二：BAG应用到实验诱导根尖周脓肿的根管内。BAG不可能充填根尖间隙，也不可能对根尖周病变起反应。实验三：将BAG应用于髓室底实验性穿孔区域，4周后，观察到许多活化的成骨细胞，并注意到该区域被钙化组织紧密填充，表明其具有高的骨传导性。但部分可见异物巨细胞和少量肉芽组织，堵塞部位有堵塞不良的危险。预计使用BAG和一些水泥的混合物可能会显示出更好的结果。