Total analysis of Pax family genes in oral carcinoma.

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In the current study, to determine the potential involvement of PAX genes in oral squamous-cell carcinoma (OSCC), we evaluated the status of PAX genes mRNA expression in OSCC cell lines, by real-time quantitative reverse transcriptase-polymerase chain reaction. A significant increase in PAX5 expression was observed in all OSCC-derived cell lines examined compared to human normal oral keratinocytes (HNOKs). The results suggest that PAX5 plays an important role during oral carcinogenesis, and that the gene may have potential as a biomarker and therapeutic target for OSCC.