Identification of a novel chimera gene not involving PAX family gene in rhabdomyosarcoma cell lines
Identification of a novel chimera gene not involving PAX family gene in rhabdomyosarcoma cell lines
批准号:
20590365
负责人:
KAKAZU Naoki
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Rhabdomyosarcoma(RMS) is characterized by the specific chromosomal translocations involving 2q35 and 1p36 bands, which generate the PAX3-and PAX7-related chimera genes, respectively. We analyzed RMS cell lines by spectral karyotyping(SKY) and detected many chromosomal translocations, in which the PAX3 and PAX7 genes were not involved. We analyzed their breakpoint regions by FISH but could not identify novel chimera genes, which suggests that the translocations were secondarily caused by chromosomal instability due to the RMS development.
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Chromosomal manipulation by site-specific recombinases and fluorescent protein-based vectors.
通过位点特异性重组酶和基于荧光蛋白的载体进行染色体操作。
DOI:
10.1371/journal.pone.0009846
发表时间:
2010-03-24
期刊:
PloS one
影响因子:
3.7
作者:
[Uemura M, Niwa Y, Kakazu N, Adachi N, Kinoshita K]
通讯作者:
Kinoshita K
DOI:
10.1158/1078-0432.ccr-08-2955
发表时间:
2009-06-15
期刊:
CLINICAL CANCER RESEARCH
影响因子:
11.5
作者:
[Miyachi, Mitsuru, Kakazu, Naoki, Hosoi, Hajime]
通讯作者:
Hosoi, Hajime
The chromosomal constitution of postmitotic neurons, assessed by neuronal nuclear transfer into oocytes and in ES cell lines derived from them
有丝分裂后神经元的染色体构成,通过神经元核转移到卵母细胞及其衍生的 ES 细胞系中进行评估
DOI:
10.1159/000230004
发表时间:
2009
期刊:
Cytogenet Genome Res
影响因子:
1.7
作者:
[T. Osada, N. Kakazu, M. Watanabe, H. Yamane, T. Yagi]
通讯作者:
T. Yagi
A novel PAX3 rearrangement in embryonal rhabdomyosarcoma
胚胎横纹肌肉瘤中的新型 PAX3 重排
DOI:
--
发表时间:
2009
期刊:
Cancer Genet Cytogenet 189(2)
影响因子:
--
作者:
[Hosoi H, Kakazu N, Konishi E, (他18名)]
通讯作者:
(他18名)
Identification of novel causative genes in mesothelioma and the elucidation of the carcinogenic mechanism
-
批准号:23590464
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2011
-
负责人:KAKAZU Naoki
-
依托单位:
The identification of the novel causative genes in embryonal rhabdomyosarcoma and the elucidation of the molecular mechanism
-
批准号:18590378
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.49万
-
财政年份:2006
-
负责人:KAKAZU Naoki
-
依托单位:
Development of automated karyotyping that allows for accurate identification of the origin of chromosome bands and subtelomeres.
-
批准号:12470519
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$3.65万
-
财政年份:2000
-
负责人:KAKAZU Naoki
-
依托单位:
Development of new spectral karyotyping (SKY) techniques in cytogenetic analysis
-
批准号:11671010
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.66万
-
财政年份:1999
-
负责人:KAKAZU Naoki
-
依托单位:
海外基金