Regulation of periodic angiogenesis through biological clock gene Clock

通过生物钟基因Clock调节周期性血管生成

• 批准号: 20592393
• 负责人: HOSOMICHI Jun
• 金额: $ 2.83万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592393/
• 关键词: 血管新生; 歯根膜; 機械的刺激; 歯周組織; VEGFR-2; β遮断薬; VEGF; bFGF; 顎関節; 咀嚼筋; 血管; 血管新生因子; PEDF

Mechanical loading is a key factor in tissue remodeling. This study examined influences of mechanical stimuli on the remodeling of periodontal tissues, mandibular bone. We hypothesised that mechanical forces, such as occlusal force and orthodontic force, promote the periodontal remodeling through angiogenesis. We firstly examined two topics as the followings : (1) influences of occlusal stimuli on blood vessels in a rat dental pulp, (2) influences of occlusal hypofunction on the teeth movement through the impaired angiogenesis in the periodontium. Secondly, we focused on the mediation of unloading-induced bone loss through sympathetic nervous activity. We examined the effect of sympathetic nervous activity on occlusal hypofunction-induced alveolar bone loss in rats using a non-selective β-adrenergic receptor antagonist. In summary these studies indicated that occlusal stimuli played a role in the maintenance and remodeling of periodontium and bone during both normal condition and teeth movement.

机械负荷是组织重塑的关键因素。这项研究检查了机械刺激对牙周组织（下颌骨）重塑的影响。我们假设机械力（例如咬合力和正畸力）通过血管生成促进了牙周重塑。我们首先检查了两个主题，作为以下内容：（1）咬合刺激对大鼠牙浆中血管的影响，（2）咬合功能低功能对牙齿通过牙周上的血管生成的影响。其次，我们专注于通过交感神经活动通过卸载引起的骨质流失的介导。我们使用非选择性的β-肾上腺素受体拮抗剂研究了交感神经活动对大鼠咬合肌功能低下诱导的肺泡骨丧失的影响。总之，这些研究表明，在正常状态和牙齿运动过程中，咬合刺激在牙周和骨骼的维持和重塑中发挥了作用。

项目成果

Usefulness of the observation on VEGF receptor-2 in rat periodontal ligament using fluorescent antibody method

荧光抗体法观察大鼠牙周膜VEGF受体2的实用性

• 发表时间: 2009
• 作者: USUMI R;ONO N;HOSOMICHI J
• 通讯作者: HOSOMICHI J

Alteration of bFGF expression with growth and age in rat molar periodontal ligament

• DOI: 10.2319/011910-38.1
• 发表时间: 2010-09-01
• 期刊: ANGLE ORTHODONTIST
• 影响因子: 3.4
• 作者: Sako, Emi;Hosomichi, Jun
• 通讯作者: Hosomichi, Jun

咬合刺激低下時における歯槽骨代謝に交感神経系が与える影響について

咬合刺激减少时交感神经系统对牙槽骨代谢的影响

• 发表时间: 2010
• 作者: 清水康広;細道純;金香佐和;小野卓史
• 通讯作者: 小野卓史

Influence of occlusal stimuli on the microvasculature in rat dental pulp

• 发表时间: 2009
• 作者: 渋谷 直樹

咬合刺激喪失がラット臼歯歯髄組織および象牙質形成に及ぼす影響について

咬合刺激丧失对大鼠磨牙牙髓组织和牙本质形成的影响

• 发表时间: 2008
• 作者: 渋谷直樹;細道純;石田雄之;相馬邦道
• 通讯作者: 相馬邦道