Analysis of mechanism in reducing pain during orthodontic tooth movement by CO_2 laser

CO_2激光减轻正畸牙移动疼痛的机制分析

• 批准号: 20592401
• 负责人: DEGUCHI Toru
• 金额: $ 3万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592401/
• 关键词: 歯の移動; 神経ペプチド; レーザー; 三次元形態計測; C-fos蛋白; グリア細胞; アストロサイト; 骨細胞

The aim of this study is to investigate the pain reducing effect and mechanism of CO2 laser during orthodontic tooth movement. In the present study, we analyzed the effect of CO2 laser in the central (medullary dorsal horn)and in the peripheral (tooth pulp, periodontal ligament)nervous system during experimental tooth movement in rats. As a result, increased c-fos known as the pain marker, was observed after experimental tooth movement, and it significantly decreased at the medullary dorsal horn after CO2 laser irradiation. On the other hand, there was no significant change in the calcitonin gene-related peptide (CGRP)and PGP9. 5 at the tooth pulp and periodontal ligament after the irradiation of CO2 laser. Furthermore, by the temperature measurements, the maximum temperatures were less than 40°C, which cannot cause tissue injury. Therefore, it is suggested that the CO2 laser reduces pain during experimental tooth movement by inhibiting c-fos neurons at the central nervous system without damaging peripheral tissue.

本研究旨在探讨CO2激光在正畸牙移动过程中的镇痛效果及其机制。在本研究中，我们分析了CO2激光在大鼠实验性牙齿移动过程中对中枢（髓后角）和外周（牙髓、牙周膜）神经系统的影响。结果，增加c-fos被称为疼痛标记物，观察实验性牙齿移动后，它显着减少后，CO2激光照射在髓背角。另一方面，降钙素基因相关肽（CGRP）和PGP 9无显著变化。5. CO_2激光照射后牙髓和牙周膜的组织学变化。此外，通过温度测量，最高温度低于40°C，这不会导致组织损伤。因此，这表明，CO2激光通过抑制中枢神经系统的c-fos神经元而不损害外周组织来减轻实验性牙齿移动过程中的疼痛。

项目成果

Miniscrews for orthodontics : From evidence-based histological, clinical, and biomechanical perspective

用于正畸的微型螺钉：从循证组织学、临床和生物力学的角度来看

• 发表时间: 2008
• 作者: 片岡伴記;橋本隆志;出口徹;白賀のり子;今井美香子;湊雅直;山本照子;山城隆;Deguchi T
• 通讯作者: Deguchi T

Histomorphometric evaluation of alveolar bone turnover between the maxilla and the mandible during experimental tooth movement in dogs

• DOI: 10.1016/j.ajodo.2006.12.013
• 发表时间: 2008-06-01
• 期刊: AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
• 影响因子: 3
• 作者: Deguchi, Toru;Takano-Yamamoto, Teruko;Garetto, Lawrence P.
• 通讯作者: Garetto, Lawrence P.

Histomorphometric Evaluation of Cortical Bone Thickness Surrounding Miniscrew for Orthodontic Anchorage

• DOI: 10.1111/j.1708-8208.2009.00197.x
• 发表时间: 2011-01-01
• 期刊: CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
• 影响因子: 3.6
• 作者: Deguchi, Toru;Yabuuchi, Toshinori;Takano-Yamamoto, Teruko
• 通讯作者: Takano-Yamamoto, Teruko

ミニスクリューを固定源として用いたラビアルおよびリンガルブラケット装置による臨床評価の比較・検討

以微型螺钉为固定源的唇舌托槽装置临床评价的比较与研究

• 发表时间: 2010
• 作者: 出口徹;寺尾文恵;菅原康代;片岡伴記;山城隆;山本照子
• 通讯作者: 山本照子

広汎型侵襲性歯周炎を伴う重度叢生症例-歯周病細菌感染度を指標とした病態の把握-

伴有广泛侵袭性牙周炎的严重拥挤病例 - 以牙周细菌感染程度为指标了解疾病状态 -

• 发表时间: 2010
• 作者: 石原嘉人;本城正;出口徹;富川和哉;高柴正悟;山城隆
• 通讯作者: 山城隆