The effect of the serotonergic descending pain inhibitory system activation by acute noticeptive stimulation on chronic notiception in the rats.

急性知觉刺激激活血清素能下行疼痛抑制系统对大鼠慢性知觉的影响。

• 批准号: 20592448
• 负责人: ONODERA Dai
• 金额: $ 2.5万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592448/
• 关键词: セロトニン; 下行性疼痛抑制系; 慢性痛; 抗うつ剤; 三叉神経脊髄路核尾側亜核; 延髄大縫線核

This study was designed to determine the effect of the serotonergic descending pain inhibitory system activation on chronic pain model rats. Chronic constriction injury (CCI) of the infraorbital nerve (ION) reduced the escape thresholds of mechanical stimulation to the facial area innervated by ION 3-7 days after. Electrical stimulation of mental nerve ipsilaretral to CCI side increased the escape thresholds of mechanical stimulation 12h after. In the same time, expression of serotonin was upregulated in the spinal trigeminal nucleus ipsilateral to stimulus side. These results suggested that the activation of the descending pain inhibitory system by mental nerve stimulation could relieve chronic notiception in ION-CCI model rats.

本研究旨在探讨5-羟色胺能下行痛抑制系统激活对慢性疼痛模型大鼠的影响。眶下神经慢性压迫伤(CCI)后3~7天，机械刺激对面神经支配部位的逃逸阈值降低。电刺激背向CCI侧的精神神经可提高12h后机械刺激的逃避阈值。同时，5-羟色胺在刺激侧同侧三叉神经脊束核表达上调。这些结果提示，精神神经刺激激活下行痛抑制系统可以减轻离子-CCI模型大鼠的慢性感觉。

项目成果

Serotonin synthesis and metabolism-related molecules in a human prostate cancer cell line

• DOI: 10.3892/ol.2011.244
• 发表时间: 2011-03-01
• 期刊: ONCOLOGY LETTERS
• 影响因子: 2.9
• 作者: Shinka, Toshiaki;Onodera, Dai;Fukumoto, Takahiro
• 通讯作者: Fukumoto, Takahiro

ラット舌痛刺激による視床下部・下垂体のストレス応答遺伝子転写の定量

大鼠舌痛刺激诱导的下丘脑和垂体中应激反应基因转录的定量

• 发表时间: 2010
• 作者: 杉本是明;庄司憲明;笹野高嗣
• 通讯作者: 笹野高嗣

Absence of sympathetic innervation and sprouting in rat dentinal tubules

大鼠牙本质小管缺乏交感神经支配和发芽

• 发表时间: 2008
• 作者: Yoichi Shimeno;Yumiko Sugawara;Masahiro Iikubo;Noriaki Shoji;Takashi Sasano
• 通讯作者: Takashi Sasano

Quantitative analysis for pain stress using CRH hnRNA expression

使用 CRH hnRNA 表达定量分析疼痛应激

• 发表时间: 2010
• 作者: Shoji N;Sugimoto K;Kataura T;Onodera D;Sasano T
• 通讯作者: Sasano T

The effectiveness of the Uchida-Kraepelin test for psychological stress: an analysis of plasma and salivary stress substances

• DOI: 10.1186/1751-0759-3-5
• 发表时间: 2009-01-01
• 期刊: BIOPSYCHOSOCIAL MEDICINE
• 影响因子: 2.1
• 作者: Sugimoto, Koreaki;Kanai, Aya;Shoji, Noriaki
• 通讯作者: Shoji, Noriaki