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The mirror neuron improve dysphagia? : Evaluation by the multi modality for functional brain imaging

镜像神经元改善吞咽困难？

基本信息

批准号：
20592469
负责人：
WATANABE Yutaka
金额：
$ 2.91万
依托单位：
Tokyo Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

项目摘要

Purpose : Mirror neurons fire when a particular action is performed and when the animal observes the same action being performed by another individual. We have demonstrated the activity of mirror neurons during swallowing-related visual stimulation, and investigated the establishment of a new form of rehabilitation. In addition, to examine clinical application of this new rehabilitation, we examined fact-finding about an obstacle of the dietary behavior of the Alzheimer's disease (AD) patients whom conventional rehabilitation had difficulty with.Methods : Subjects were 15 healthy individuals. Brain activity during the presentation of swallowing movements was measured using 3T-fMRI and MEG. The experimental method consisted of showing 16 types of stimulus video to subjects, comprising general videos and fluoroscopic videos. In MEG study, swallowing-related stimuli comprised an animated image of the left profile of a person swallowing water with laryngeal elevation as a visual swallowing … More trigger stimulus, and a swallowing sound as an auditory swallowing trigger stimulus. We measured the brain signal by 3T-fMRI and MEG and analyzed.In fact-finding survey of the diet behavior of the AD patients, The enrolled AD patients, totaled 150 patients, who were residents of institutions or group homes. The patients underwent an eating behavior examination, cognitive assessment, neurological examination, and vital function tests. The eating behavior examination consisted of observation of the patients at mealtime. Items assessed eating behavior included the number of feeding cycles, stopping of eating or agitation, and dysfunction.Results : Activity in mirror neuron areas was observed during water swallowing, fluoroscopic video. Activity in mirror neuron areas was left-hemisphere-dominant during the presentation of WXL and right-hemisphere-dominant during the presentation of CXL. With animation stimuli (animation stimulus, animation+swallowing sound stimuli, animation+artificial sound stimuli), activation in mirror neuron areas, corresponding to mirror neurons, was observed between 620 and 720 ms before the trigger.In fact-finding survey of the diet behavior of the AD patients, Logistic regression analysis performed to identify factors with a significant affect on decreased independence in eating were difficulty in beginning a meal, presence of dysphagia signs, and the severity of dementia.Conclusion : Evaluation by the multi modality for functional brain imaging, I accepted activity in the mirror neuron of the deglutition. In addition, that it was necessary to promote adjustment of the meal environment that promoted a meal start to maintain an independence feeding and a meal start was suggested by fact-finding of the dietary behavior of the AD patient. The possibility that could improve a problem of the appetite of the AD patients that it had been assumed that I was difficult till now by performing the appetite support that I used a mirror neuron system for was suggested by this. Less

目的：当一个特定的动作被执行时，当动物观察到另一个人正在执行相同的动作时，镜像神经元就会被激活。我们已经证明了吞咽相关的视觉刺激过程中镜像神经元的活动，并研究了建立一种新的康复形式。此外，检查这种新的康复的临床应用，我们研究了事实发现的阿尔茨海默氏病（AD）患者的饮食行为的障碍，其中常规康复有difficult with.Methods：主题是15个健康人。吞咽运动过程中的大脑活动进行了测量，使用3 T-fMRI和MEG。实验方法包括向受试者显示16种类型的刺激视频，包括普通视频和荧光透视视频。在MEG研究中，与吞咽相关的刺激包括一个人左侧轮廓的动画图像，该人以喉部抬高的方式喝水，作为视觉吞咽 ...更多信息触发刺激，以及作为听觉吞咽触发刺激的吞咽声音。在对AD患者饮食行为的实况调查中，共纳入150例AD患者，均为机构或集体之家的居民。患者接受饮食行为检查、认知评估、神经系统检查和生命功能测试。饮食行为检查包括进餐时观察患者。评估进食行为的项目包括喂养周期的数量，停止进食或搅拌，和dysfunction.Results：在吞咽水，荧光透视视频期间观察到镜像神经元区的活动。镜像神经元区的活动是左半球主导的WXL和右半球主导的CXL的介绍期间。用动画刺激（动画刺激、动画+吞咽声音刺激、动画+人工声音刺激），在触发前620和720 ms之间观察到对应于镜像神经元的镜像神经元区域的激活。进行逻辑回归分析，以确定对进食独立性下降有显著影响的因素是开始进食困难，结论：通过多模态脑功能成像评估，我接受吞咽镜像神经元的活动。此外，通过对AD患者的饮食行为的事实调查，提示有必要促进促进进餐开始的进餐环境的调整以维持独立进食和进餐开始。这种可能性可以改善AD患者的食欲问题，这一直被认为是我迄今为止很难通过执行食欲支持，我使用了镜像神经元系统，这是由这个建议。少