Mechanisms of lipid raft disturbance and role of raft-related neurogenerational molecules in the GM3 only mice

在神经节苷脂组成正常的仅GM3小鼠的脑中，脂筏蛋白的定位随着年龄的增长而转移到非筏区域。Ninjurin2是神经再生相关分子之一，在GM3单药小鼠中枢神经系统中表达下调。Ninjurin2定位于筏区，与嗜同性细胞粘附和神经突起生长增加有关。这些数据表明，筏组成的干扰加速神经退行性变的GM3只小鼠。

In the brain of the GM3 only mice that defected normal gangliosides composition, localization of lipid raft proteins shifted to non-raft region with aging. Ninjurin2, reported as one of the neuroregeneration-related molecules, was down-regulated in the GM3 only mice in central nervous system. Ninjurin2 localized at raft region and related to homophilic cell adhesion and increased neurite outgrowth. These date suggested that disturbance of raft compositions accelerate neurodegeneration in the GM3 only mice.