Elucidation of a novel skin and hair follicle mutation gene "matted (ma)" in mouse.

本研究的目的是鉴定斑纹小鼠皮肤和毛囊缺陷的突变基因，并阐明其异常皮肤和毛囊形成的病理机制。本研究通过连锁分析，在小鼠3号染色体上的两个DNA标记（D3Mit40, D3Mit49）之间定位了ma位点。负责DNA区域的大小约为1,100 k碱基，该区域估计有48个基因。然而，到目前为止，还没有从ma小鼠的候选基因的皮肤dna中检测到任何突变序列。

The aim of this study was to identify the mutated gene responsible for defects of skin and hair follicle in matted (ma) mice, and to elucidate the pathologic mechanisms of its abnormal skin and hair follicle formation. In this study, the ma locus was mapped between the two DNA markers (D3Mit40, D3Mit49) on mouse chromosome 3 by linkage analysis. The size of the responsible DNA region is about 1,100 Kbases, and there are 48 genes estimated in the region. However so far, any mutated sequence have not been detected from skin cDNAs of the candidate genes in ma mice.