Measurement of Mechanical Properties on Plasma Proteins and Computational Simulation of Primary Thrombosis Formation

血浆蛋白机械特性的测量和原发性血栓形成的计算模拟

• 批准号: 20700374
• 负责人: MORI Daisuke
• 金额: $ 2.66万
• 依托单位: Hachinohe National College of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20700374/
• 关键词: 一次血栓; 血漿タンパク分子; 計算生体力学

We developed a method to analyze platelet adhesion and aggregation computationally, taking into account the distinct properties of two plasma proteins, vonWillebrand factor and fibrinogen. In this method, the hydrodynamic interactions between platelet particles under simple shear flow were simulated using Stokesian dynamics. The binding force between particles mediated by vonWillebrand factor and fibrinogen was modeled.

我们开发了一种方法来分析血小板粘附和聚集计算，考虑到两个血浆蛋白，vonWillebrand因子和纤维蛋白原的不同属性。在该方法中，采用斯托克斯动力学方法模拟了简单剪切流场中片状颗粒之间的流体动力学相互作用。建立了由vonWillebrand因子介导的颗粒与纤维蛋白原之间的结合力模型。

项目成果

Three-dimensional Analysis of Flow Disturbances Caused by Clots in Inferior Vena Cava Filters

• DOI: 10.1016/j.jvir.2010.12.024
• 发表时间: 2011-06-01
• 期刊: JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
• 影响因子: 2.9
• 作者: Rahbar, Elaheh;Mori, Daisuke;Moore, James E., Jr.
• 通讯作者: Moore, James E., Jr.

Computational study on effect of red blood cells on primary thrombus formation

红细胞对原发性血栓形成影响的计算研究

• 发表时间: 2008
• 期刊: Thrombosis Research
• 影响因子: 7.5
• 作者: D. Mori;K. Yano;K. Tsubota;T. Ishikawa;S. Wada and T. Yamaguchi
• 通讯作者: S. Wada and T. Yamaguchi