Intracellular transport of DISC1/Neuregulin-1 and schizophrenia

DISC1/Neuregulin-1 的细胞内转运与精神分裂症

• 批准号: 23700443
• 负责人: MORI Daisuke
• 金额: $ 2.91万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700443/
• 关键词: 分子; 細胞; 神経生物学; 統合失調症; DISC1; ニューレグリン; Neuregulin-1

We hypothesized that DISC1 would be involved in vesicular transport of various proteins and mRNAs which maintain neuronal function. Previously, we have identified direct interaction of DISC1 and Neuregulin-1, which is a ligand of ErbB3 and ErbB4. To understand the sense of their association, we have attempted to analyze their common interacting proteins. As a result of the comprehensive screenings, we have identified AP family proteins, which have essential roles for intracellular vesicle trafficking. Moreover, we have established a new experimental system that enables us to quantify the secretion of processed Neuregulin-1 by immunoblotting. We found that the processed Neuregulin-1 was decreased in cultured hippocampal neuron from DISC1-deficient mice. 交付決定額

We hypothesized that DISC1 would be involved in vesicular transport of various proteins and mRNAs which maintain neuronal function. Previously, we have identified direct interaction of DISC1 and Neuregulin-1, which is a ligand of ErbB3 and ErbB4. To understand the sense of their association, we have attempted to analyze their common interacting proteins. As a result of the comprehensive screenings, we have identified AP family proteins, which have essential roles for intracellular vesicle trafficking. Moreover, we have established a new experimental system that enables us to quantify the secretion of processed Neuregulin-1 by immunoblotting. We found that the processed Neuregulin-1 was decreased in cultured hippocampal neuron from DISC1-deficient mice. Decision delivery

项目成果

Molecular regulation of pro-Neuregulin intracellular trafficking

神经调节蛋白原细胞内运输的分子调控

• 发表时间: 2012
• 作者: 森大輔;貝淵弘三
• 通讯作者: 貝淵弘三

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse

• DOI: 10.1093/hmg/ddr400
• 发表时间: 2011-12-01
• 期刊: HUMAN MOLECULAR GENETICS
• 影响因子: 3.5
• 作者: Kuroda, Keisuke;Yamada, Shinnosuke;Kaibuchi, Kozo
• 通讯作者: Kaibuchi, Kozo

ニューレグリン前駆体の細胞内輸送

神经调节蛋白前体的细胞内转运

• 发表时间: 2012
• 作者: 森大輔;貝淵弘三;森大輔
• 通讯作者: 森大輔