Intracellular transport of DISC1/Neuregulin-1 and schizophrenia

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We hypothesized that DISC1 would be involved in vesicular transport of various proteins and mRNAs which maintain neuronal function. Previously, we have identified direct interaction of DISC1 and Neuregulin-1, which is a ligand of ErbB3 and ErbB4. To understand the sense of their association, we have attempted to analyze their common interacting proteins. As a result of the comprehensive screenings, we have identified AP family proteins, which have essential roles for intracellular vesicle trafficking. Moreover, we have established a new experimental system that enables us to quantify the secretion of processed Neuregulin-1 by immunoblotting. We found that the processed Neuregulin-1 was decreased in cultured hippocampal neuron from DISC1-deficient mice. 交付決定額