Apoptosis and decreased neurogenesis in the hippocampal dentate gyrus of SAMP8 mice with occlusal disharmony.

我们最近证明，在衰老加速小鼠（SAMP8）中，提高咬合力（bite-raised）可显著降低细胞增殖、存活和新生细胞向神经元的分化。慢性应激，甚至慢性轻度应激，降低脑源性神经营养因子（BDNF）和增加循环糖皮质激素水平导致海马细胞凋亡。本实验研究了咬伤升高条件对SAMP8小鼠海马齿状回（DG） BDNF、脱氧核苷酸转移酶dUTP镍端标记阳性凋亡细胞的影响。

We recently demonstrated that raising the bite (bite-raised) significantly decreased cell proliferation, survival, and differentiation of newborn cells into neurons in aged senescence-accelerated mice (SAMP8). Chronic stress, even chronic mild stress, decrease Brain-derived neurotrophic factor(BDNF) and increases in circulating glucocorticoid levels lead to apoptosis in the hippocampus. Here we examined the effect of the bite-raised condition on BDNF, deoxynucleotidyl transferase dUTP nick-end labeling-positive apoptotic cells in the hippocampal dentate gyrus (DG) of SAMP8 mice.