Preventive effect of silk protein, sericin, on metabolic syndrome

丝蛋白丝胶对代谢综合征的预防作用

基本信息

  • 批准号:
    20700597
  • 负责人:
  • 金额:
    $ 2.75万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 财政年份:
    2008
  • 资助国家:
    日本
  • 起止时间:
    2008 至 2010
  • 项目状态:
    已结题

项目摘要

This study was performed to examine the effect of dietary sericin on the lipid and carbohydrate metabolisms in rats fed high-fat diet. Consumption of sericin significantly reduced serum and liver lipids and the activities of the lipogenic enzymes. Dietary sericin suppressed the increases in plasma glucose and insulin levels after intraperitoneal glucose injection. Dietary sericin caused a marked elevation in serum adiponectin. These results imply that the increase in serum adiponectin by sericin intake may, at least in part, contribute to the protective effect against hyperlipidemia, fatty liver and glucose intolerance in rats fed a high-fat diet. Consumption of sericin markedly elevated fecal immunoglobulin A (IgA, index of intestinal immune function), mucins (index of intestinal barrier function) and cecal organic aicds in rats fed the high-fat diet. There was an inverse correlation between serum triglyceride and cecal acetate. These results imply that sericin is a useful agent for improving lipid and carbohydrate metabolisms and intestinal luminal environments in rats fed a high-fat diet.
本研究旨在探讨饲粮中添加丝胶蛋白对高脂饮食大鼠脂类和碳水化合物代谢的影响。消耗的丝胶蛋白显着降低血清和肝脏脂质和脂肪生成酶的活动。饲粮中的丝胶蛋白抑制了腹腔注射葡萄糖后血糖和胰岛素水平的升高。饲粮中添加丝胶引起血清脂联素显著升高。这些结果表明,血清脂联素的增加,由丝胶摄入量可能,至少部分,有助于对高脂血症,脂肪肝和葡萄糖耐受不良的大鼠喂养高脂肪饮食的保护作用。在高脂饲料喂养的大鼠中,食用丝胶蛋白显著升高粪便免疫球蛋白A(伊加,肠道免疫功能指数)、粘蛋白(肠道屏障功能指数)和盲肠有机酸。血清甘油三酯与盲肠乙酸酯呈负相关。这些结果表明,丝胶蛋白是一个有用的代理,以改善脂质和碳水化合物代谢和肠道管腔环境的高脂肪饮食大鼠。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Consumption of sericin reduces serum lipids, ameliorates glucose tolerance and elevates serum sdiponectin in rats fed a high-fat diet.
摄入丝胶可以降低高脂饮食大鼠的血清脂质,改善葡萄糖耐量并提高血清脂联素。
絹タンパク質セリシンの腸内環境に及ぼす影響
丝蛋白丝胶对肠道环境的影响
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    岡崎由佳子;他;岡崎由佳子・辻本和久・佐々木真宏・加藤範久
  • 通讯作者:
    岡崎由佳子・辻本和久・佐々木真宏・加藤範久
絹タンパク質セリシンの盲腸有機酸含量と肝障害に及ぼす影響
丝蛋白丝胶对盲肠有机酸含量及肝损伤的影响
  • DOI:
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yukako Okazaki;et. Al.;岡崎由佳子・辻本和久・佐々木真宏・加藤範久
  • 通讯作者:
    岡崎由佳子・辻本和久・佐々木真宏・加藤範久
Consumption of Sericin Reduces Serum Lipids, Ameliorates Glucose Tolerance and Elevates Serum Adiponectin in Rats Fed a High-Fat Diet
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

OKAZAKI Yukako其他文献

OKAZAKI Yukako的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('OKAZAKI Yukako', 18)}}的其他基金

Effects of nutritional conditions on induction of colonic alkaline phosphatase activity by dietary nondigestible carbohydrates, and those analyses
营养条件对膳食不消化碳水化合物诱导结肠碱性磷酸酶活性的影响以及这些分析
  • 批准号:
    18K02244
  • 财政年份:
    2018
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Elucidation of physiological function of colonic ALP and beta-glucosidase activities, and the effects of food factors on these enzymes
阐明结肠 ALP 和 β-葡萄糖苷酶活性的生理功能,以及食物因素对这些酶的影响
  • 批准号:
    15K00836
  • 财政年份:
    2015
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Curative and preventive effects of dietary lily bulb on colonic luminal environment and lifestyle-related diseases
食用百合对结肠腔环境及生活方式相关疾病的治疗和预防作用
  • 批准号:
    24700845
  • 财政年份:
    2012
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)

相似海外基金

Regulation of macrophage function by adipose derived secreted protein and its involvement in NASH
脂肪源性分泌蛋白对巨噬细胞功能的调节及其在 NASH 中的作用
  • 批准号:
    18K16205
  • 财政年份:
    2018
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Impact of adipokines on lower urinary tract functions
脂肪因子对下尿路功能的影响
  • 批准号:
    17K11178
  • 财政年份:
    2017
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Elucidation of the mechanism of urinary stone formation in metabolic syndrome and its application to molecular target treatment
代谢综合征尿路结石形成机制的阐明及其在分子靶向治疗中的应用
  • 批准号:
    15H04976
  • 财政年份:
    2015
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
A comprehensive study of the establishment of urolithiasis prophylaxis from both genetic factors and environmental factors
从遗传因素和环境因素两方面综合研究建立尿石症预防方案
  • 批准号:
    15K10626
  • 财政年份:
    2015
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
An exploratory/systematic cohort study on the relationship between childhood weight increase and the development of obesity/metabolic syndrome in adolescence
关于儿童体重增加与青春期肥胖/代谢综合征发展之间关系的探索性/系统队列研究
  • 批准号:
    25461559
  • 财政年份:
    2013
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Relationship between Alcohol Intake and both Adiponectin production and Lifestyle-related Disease Risk in general Japanese population.
日本普通人群中酒精摄入量与脂联素产生和生活方式相关疾病风险之间的关系。
  • 批准号:
    24590802
  • 财政年份:
    2012
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Role for periarterial adipose tissue in atherosclerosis in obesity
动脉周围脂肪组织在肥胖症动脉粥样硬化中的作用
  • 批准号:
    24591057
  • 财政年份:
    2012
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Cross sectional study from gene and environmental factor towards
从基因和环境因素的横断面研究
  • 批准号:
    23592374
  • 财政年份:
    2011
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Search for novel biomarkers associated with onset of metabolic syndrome and resistance to body weight reduction
寻找与代谢综合征发作和体重减轻抵抗力相关的新型生物标志物
  • 批准号:
    23590704
  • 财政年份:
    2011
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Establishment of new strategy for preventing the prothrombotic tendency of metabolic syndrome
建立预防代谢综合征血栓形成倾向的新策略
  • 批准号:
    23590905
  • 财政年份:
    2011
  • 资助金额:
    $ 2.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了