Preventive effect of silk protein, sericin, on metabolic syndrome

丝蛋白丝胶对代谢综合征的预防作用

• 批准号: 20700597
• 负责人: OKAZAKI Yukako
• 金额: $ 2.75万
• 依托单位: Fuji Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20700597/
• 关键词: セリシン; メタボリックシンドローム; アディポサイトカイン; 腸内環境; 栄養学; ラット; 高脂肪食; 盲腸有機酸; 腸内細菌叢; 肝障害; 血清AST; 血清ALT; アディポネクチン; 脂質代謝; 糖代謝; IgA; 脂肪酸合成関連酵素; 肝臓脂肪; 高脂血症

This study was performed to examine the effect of dietary sericin on the lipid and carbohydrate metabolisms in rats fed high-fat diet. Consumption of sericin significantly reduced serum and liver lipids and the activities of the lipogenic enzymes. Dietary sericin suppressed the increases in plasma glucose and insulin levels after intraperitoneal glucose injection. Dietary sericin caused a marked elevation in serum adiponectin. These results imply that the increase in serum adiponectin by sericin intake may, at least in part, contribute to the protective effect against hyperlipidemia, fatty liver and glucose intolerance in rats fed a high-fat diet. Consumption of sericin markedly elevated fecal immunoglobulin A (IgA, index of intestinal immune function), mucins (index of intestinal barrier function) and cecal organic aicds in rats fed the high-fat diet. There was an inverse correlation between serum triglyceride and cecal acetate. These results imply that sericin is a useful agent for improving lipid and carbohydrate metabolisms and intestinal luminal environments in rats fed a high-fat diet.

本研究旨在探讨饲粮中添加丝胶蛋白对高脂饮食大鼠脂类和碳水化合物代谢的影响。消耗的丝胶蛋白显着降低血清和肝脏脂质和脂肪生成酶的活动。饲粮中的丝胶蛋白抑制了腹腔注射葡萄糖后血糖和胰岛素水平的升高。饲粮中添加丝胶引起血清脂联素显著升高。这些结果表明，血清脂联素的增加，由丝胶摄入量可能，至少部分，有助于对高脂血症，脂肪肝和葡萄糖耐受不良的大鼠喂养高脂肪饮食的保护作用。在高脂饲料喂养的大鼠中，食用丝胶蛋白显著升高粪便免疫球蛋白A（伊加，肠道免疫功能指数）、粘蛋白（肠道屏障功能指数）和盲肠有机酸。血清甘油三酯与盲肠乙酸酯呈负相关。这些结果表明，丝胶蛋白是一个有用的代理，以改善脂质和碳水化合物代谢和肠道管腔环境的高脂肪饮食大鼠。

项目成果

Consumption of sericin reduces serum lipids, ameliorates glucose tolerance and elevates serum sdiponectin in rats fed a high-fat diet.

摄入丝胶可以降低高脂饮食大鼠的血清脂质，改善葡萄糖耐量并提高血清脂联素。

• 期刊: Bioscience, Biotechnology, and Biochemistry (印刷中)
• 作者: Yukako Okazaki;et. Al.
• 通讯作者: et. Al.

絹タンパク質セリシンの腸内環境に及ぼす影響

丝蛋白丝胶对肠道环境的影响

• 发表时间: 2010
• 作者: 岡崎由佳子;他;岡崎由佳子・辻本和久・佐々木真宏・加藤範久
• 通讯作者: 岡崎由佳子・辻本和久・佐々木真宏・加藤範久

絹タンパク質セリシンの盲腸有機酸含量と肝障害に及ぼす影響

丝蛋白丝胶对盲肠有机酸含量及肝损伤的影响

• 发表时间: 2011
• 作者: Yukako Okazaki;et. Al.;岡崎由佳子・辻本和久・佐々木真宏・加藤範久
• 通讯作者: 岡崎由佳子・辻本和久・佐々木真宏・加藤範久

Consumption of Sericin Reduces Serum Lipids, Ameliorates Glucose Tolerance and Elevates Serum Adiponectin in Rats Fed a High-Fat Diet

• DOI: 10.1271/bbb.100065
• 发表时间: 2010-08-01
• 期刊: BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
• 影响因子: 1.6
• 作者: Okazaki, Yukako;Kakehi, Shoko;Kato, Norihisa
• 通讯作者: Kato, Norihisa