Bioactive interface based on electrochemical nano-processing

基于电化学的生物光刻技术被集成到普通原子力显微镜（AFM）配置中，以对蛋白质和活细胞进行图像化。图像化过程可以很容易地构建到AFM系统中，使用一个简单制造的电化学AFM探针和一个aa大小的干电池。该系统使我们能够减小图案尺寸，并在原位对电化学处理过的表面进行成像。同时，还验证了小区扩展的原位定向控制。

The electrochemical-based biolithography technique was integrated into an ordinary atomic force microscope (AFM) configuration to pattern proteins and living cells. The patterning procedure could readily be built into an AFM system using a simply fabricated electrochemical AFM probe with an AA-size dry battery. This system enabled us to decrease the pattern size and to image the electrochemically treated surface in situ. Also, in-situ directional control of cell extension was demonstrated.