Neuroimaging, pharmacological and genetic studies of the oculomotor system in healthy and schizophrenic individuals

健康和精神分裂症患者动眼系统的神经影像学、药理学和遗传学研究

• 批准号: 53777159
• 负责人: Professor Dr. Ulrich Ettinger
• 金额: --
• 依托单位: Abteilung Allgemeine Psychologie I
• 依托单位国家: 德国
• 项目类别: Independent Junior Research Groups
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/53777159?language=en
• 关键词: Neuroimaging; pharmacological; genetic; studies; oculomotor

Deficits in oculomotor control are well validated endophenotypes of schizophrenia. In a project currently funded by a DFG Emmy Noether Programme I am investigating associations of genetic polymorphisms with smooth pursuit and antisaccade eye movements as well as their underlying neural mechanisms. This work will contribute towards our understanding of the mechanistic pathways of schizophrenia risk polymorphisms. In the original application (submitted March 2007) I proposed to study 120 patients with a diagnosis of schizophrenia and 120 healthy controls. However, recent evidence from our group as well as others has shown that much larger discovery samples in combination with independent replication samples are needed to reliably show gene effects at the neurocognitive and oculomotor level. Therefore, I would like to apply to obtain funding for (1) recruiting and testing a further 400 healthy volunteers to perform oculomotor (as well as neuropsychological) tasks and (2) extracting DNA and genotyping schizophrenia risk polymorphisms. The proposed extension of this discovery sample in combination with neuroimaging data on a subset of participants as well as large replication samples drawn from international collaborations would allow me to build up a substantial database of oculomotor endophenotypes and molecular genetics. This database would allow, for the first time, reliably assessing associations between risk polymorphisms and these well validated schizophrenia endophenotypes.

视力控制缺陷是被充分证实的精神分裂症内表型。在目前由DFG Emmy Noether项目资助的一个项目中，我正在调查遗传多态性与平稳追踪和反扫视眼球运动及其潜在神经机制的关联。这项工作将有助于我们对精神分裂症风险多态性的机制途径的理解。在最初的申请（2007年3月提交）中，我提议研究120名诊断为精神分裂症的患者和120名健康对照。然而，我们小组以及其他人最近的证据表明，需要更大的发现样本与独立复制样本相结合，才能可靠地显示神经认知和眼科水平的基因效应。因此，我想申请获得资金，用于（1）招募和测试另外400名健康志愿者，以执行眼科（以及神经心理学）任务，以及（2）提取DNA并对精神分裂症风险多态性进行基因分型。这一发现样本的拟议扩展与参与者子集的神经影像学数据以及从国际合作中提取的大型复制样本相结合，将使我能够建立一个关于眼内表型和分子遗传学的实质性数据库。这个数据库将允许，第一次，可靠地评估风险多态性和这些经过充分验证的精神分裂症内表型之间的关联。

项目成果

Neural mechanisms of smooth pursuit eye movements in schizotypy

• DOI: 10.1002/hbm.22632
• 发表时间: 2015-01
• 期刊: Human Brain Mapping
• 影响因子: 4.8
• 作者: I. Meyhöfer;M. Steffens;A. Kasparbauer;P. Grant;B. Weber;U. Ettinger

Association of COMT and SLC6A3 polymorphisms with impulsivity, response inhibition and brain function

COMT 和 SLC6A3 多态性与冲动、反应抑制和脑功能的关联

• DOI: 10.1016/j.cortex.2015.07.002
• 发表时间: 2015
• 期刊: Cortex
• 影响因子: 3.6
• 作者: Kasparbauer AM;Merten N;Aichert DS;Wöstmann N;Meindl T;Rujescu D;Ettinger U
• 通讯作者: Ettinger U

Preliminary findings on the heritability of the neural correlates of response inhibition

反应抑制神经相关因素遗传性的初步发现

• DOI: 10.1016/j.biopsycho.2014.07.017
• 发表时间: 2014
• 期刊: Biological Psychology
• 影响因子: 2.6
• 作者: Macare C;Meindl T;Nenadic I;Rujescu D;Ettinger U
• 通讯作者: Ettinger U

Methylphenidate Effects on Brain Activity as a Function of SLC6A3 Genotype and Striatal Dopamine Transporter Availability

哌甲酯对大脑活动的影响与 SLC6A3 基因型和纹状体多巴胺转运蛋白可用性有关

• DOI: 10.1038/npp.2014.240
• 发表时间: 2015
• 期刊: Neuropsychopharmacology
• 影响因子: 7.6
• 作者: Kasparbauer AM;Rujescu D;Riedel M;Pogarell O;Costa A;Meindl T;la Fougère C;Ettinger U
• 通讯作者: Ettinger U

Sensorimotor gating and D2 receptor signalling: evidence from a molecular genetic approach.

• DOI: 10.1017/s1461145711001787
• 发表时间: 2012-11
• 期刊: The international journal of neuropsychopharmacology
• 作者: C. Völter;M. Riedel;N. Wöstmann;D. Aichert;S. Lobo;Anna Costa;A. Schmechtig;D. Collier;A. Hartmann;I. Giegling;H. Möller;B. Quednow;D. Rujescu;V. Kumari;U. Ettinger