Preparation of composition-graded spherical hollow particle by spray-drying method

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Spray-drying method is a process that produces microspheres by spraying a solution of polymer or drug in a warm drying chamber. The atomized droplets are dried first at their surfaces, and the solution components become concentrated on the droplet surfaces to form hollow particles. When a solution of two components with different solubility parameters, i.e. calcium hydrogen phosphate anhydride (CaHPO4, DCPA) and acesulfame-potassium, was sprayed, the former with higher solubility was concentrated first in the outer layer of the droplet surface, and then the latter with lower solubility in the inner layer. This result demonstrates that the spray-drying technique permits the one-step preparation of composition-graded spherical particles.