Suppression of Sprouty2 Induces Periodontal Tissue Regeneration.

Sprouty被鉴定为果蝇成纤维细胞生长因子（FGF）受体的抑制剂。在哺乳动物中，已经鉴定了四种Sprouty，并且特别是Sprouty 2作为受体酪氨酸激酶（RTK）信号传导的负调节剂发挥作用。本研究的目的是探讨Sprouty2是否可以成为牙周组织再生的新治疗靶点。抑制Sprouty2诱导成骨细胞的细胞增殖和骨矿化，而抑制牙龈上皮细胞的细胞增殖。换句话说，抑制Sprouty2可以有效地允许牙槽骨生长，阻止牙龈上皮细胞向骨缺损向内生长，以及引导组织再生（GTR）方法的效果。

Sprouty was identified as an inhibitor of fibroblast growth factor (FGF) receptor in Drosophila. In mammals, four Sproutys have been identified, and specifically Sprouty2 functions as a negative regulator of receptor tyrosine kinases (RTKs) signaling. The purpose of this study was to investigate whether Sprouty2 could be new therapeutic targets for periodontal tissue regeneration. Suppression of Sprouty2 induced cell proliferation and bone mineralization of osteoblastic cells, while it diminished cell proliferation of gingival epithelial cells. In other words, inhibition of Sprouty2 may effectively allow alveolar bone to grow, with blocking the ingrowth of gingival epithelial cells toward bony defects, as well as an effect of guided tissue regeneration (GTR) methods.