Periodontal regenerative effect by inhibition of Sprout2 protein.

Sprouty2是受体酪氨酸激酶(RTKs)信号的负调节因子。本研究的目的是探讨Sprouty2能否成为牙周组织再生的新的治疗靶点。抑制Sprouty2诱导成骨细胞的增殖和分化，同时抑制牙龈上皮细胞的增殖。换句话说，抑制Sprouty2可以有效地允许牙槽骨生长，阻止牙龈上皮细胞向骨缺损的内生，以及引导组织再生(GTR)方法的效果

Sprouty2 functions as a negative regulator of receptor tyrosine kinases(RTKs) signaling. The purpose of this study was to investigate whether Sprouty2 could be new therapeutic targets for periodontal tissue regeneration. Suppression of Sprouty2 induced cell proliferation and differentiation of osteoblastic cells, while it diminished cell proliferation of gingival epithelial cells. In other words, inhibition of Sprouty2 may effectively allow alveolar bone to grow, with blocking the ingrowth of gingival epithelial cells toward bony defects, as well as an effect of guided tissue regeneration(GTR) methods