Efficacy of Interspinous Process Fusion with Recombinant Human Bone Morphogenetic Protein-2 Delivered by a Synthetic Polymer and β-Tricalcium Phosphate

合成聚合物和 β-磷酸三钙传递的重组人骨形态发生蛋白 2 棘突间融合的功效

• 批准号: 20890196
• 负责人: TOYODA Hiromitsu
• 金额: $ 2.11万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890196/
• 关键词: 骨形成蛋白; 合成ポリマー; リン酸カルシウム; 脊椎; 薬物伝導系

Regular spinal interbody fusion and posterolateral fusion involve the use of large incisions, dissection, and partial transection of the paravertebral muscle to expose the posterior spine. On the other hand, the approach to perform an interspinous process fusion involves only muscular stripping and preserves almost all structural components of the spine. If interspinous process fusion by use of Bone morphogenetic proteins (BMPs) is successfully achieved, it could reduce the axial compressive load on the vertebral column. This method would be one of the less morbid surgical options for treatment of lumbar disorders. In this study, we attempted to achieve an interspinous process fusion and evaluate its efficacy in experimental rabbit models by using a delivery system for recombinant human (rh) BMP-2. We achieved solid interspinous process fusion in experimental rabbit models by implanting a biodegradable bone-inducing implant composed of 60μg of rhBMP-2 within a period of 8 weeks. The efficacy of the interspinous process fusion was indicated by the stabilization of the spinal column and decrease in the intradiscal pressure due to axial compressive loading.

常规的椎体间融合术和后外侧融合术需要使用大的切开、椎旁肌的解剖和部分横断来显露后路脊柱。另一方面，进行棘间融合的方法只涉及肌肉剥离，并保留了几乎所有的脊柱结构成分。如果成功地利用骨形态发生蛋白(BMPs)实现棘突间融合，可以减轻脊柱的轴向压缩负荷。这种方法将是治疗腰椎疾病的病态较少的手术选择之一。在这项研究中，我们试图通过使用重组人(Rh)BMP-2的递送系统来实现棘间融合并评估其在实验性兔模型中的效果。通过植入60μg重组人骨形态发生蛋白-2组成的可生物降解的骨诱导植入物，在8周内在实验兔模型上实现了坚实的棘间融合。椎间融合术的疗效体现在脊柱的稳定和轴向压缩负荷引起的椎间盘内压力的降低。

项目成果

Efficacy of Interspinous Process Fusion with Recombinant Human Bone Morphogenetic Protein-2 with Synthetic Polymer and b-Tricalcium

重组人骨形态发生蛋白-2与合成聚合物和b-三钙融合棘突间的功效

• 发表时间: 2010
• 作者: Tomiya Matsumoto;Hiromitsu Toyoda;Sho Dohzono;Hiroaki Nakamura;Kunio Takaoka
• 通讯作者: Kunio Takaoka

X線学的変化からみた顕微鏡下片側進入両側除圧術の中長期臨床成績

从影像学变化看显微单侧入路双侧减压的中长期临床结果

• 发表时间: 2008
• 作者: 豊田宏光;中村博亮;小西定彦;加藤相勲;堂園将;松田英樹
• 通讯作者: 松田英樹

Effect of preserving paraspinal muscles on postoperative axial pain in the selective cervical laminoplasty

• DOI: 10.1097/brs.0b013e318178e607
• 发表时间: 2008-06-15
• 期刊: SPINE
• 影响因子: 3
• 作者: Kato, Minori;Nakamura, Hiroaki;Matsuda, Hideki
• 通讯作者: Matsuda, Hideki

External hip protectors are effective for the elderly with higher-than-average risk factors for hip fractures

• DOI: 10.1007/s00198-008-0824-7
• 发表时间: 2009-09-01
• 期刊: OSTEOPOROSIS INTERNATIONAL
• 影响因子: 4
• 作者: Koike, T.;Orito, Y.;Takaoka, K.
• 通讯作者: Takaoka, K.

Matsuda H Clinical Outcome of Microsurgical Bilateral Decompression via Unilateral Approach for Lumbar Canal Stenosis

Matsuda H 单侧入路显微手术双侧减压治疗腰椎管狭窄症的临床结果

• 期刊: Minimum 5-Year Follow-Up Spine (in press)
• 作者: Toyoda H;Nakamura F;Konishi S;Dohzono S
• 通讯作者: Dohzono S