Mechanisms of regulation of noradrenaline and dopamine efflux in the nucleus accumbens

口腔运动障碍是一种以重复刻板的口腔运动为特征的神经系统综合征。该疾病的详细生物学基础尚不清楚，但行为学研究表明，延髓多巴胺能神经元在诱导大鼠重复性下颌运动中起着关键作用。已知在该核内存在密切的去甲肾上腺素-多巴胺相互作用。因此，在本研究中，我们调查的调节机制，多巴胺能和去甲肾上腺素能活动在自由活动的大鼠，使用在体脑微透析技术。

Oral dyskinesia is a neurological syndrome which is characterized by the repetitive stereotyped oral movement. The detailed biological basis of the disorder remains unclear, but the behavioural studies suggest that the accumbal dopaminergic neurons play a pivotal role for the induction of repetitive jaw movements of rats. It is known that there exists a close noradrenaline-dopamine interaction within this nucleus. Therefore, in the present study, we investigated the mechanisms of the regulation of accumbal dopaminergic and noradrenergic activity in freely moving rats, using the in vivo brain microdialysis technique.